Evidence map›Paper›PMID 26344778›Full record

ArticleThe Journal of nutritional biochemistry2015

Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice.

Hisham Qosa, Loqman A Mohamed, Yazan S Batarseh, Saeed Alqahtani, Baher Ibrahim, Harry LeVine, Jeffrey N Keller, Amal Kaddoumi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutritional biochemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.

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  8. Cerebral amyloid angiopathy: a narrative review.Frontiers in aging neuroscience · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Hisham QosaDepartment of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209, USA.
Loqman A MohamedDepartment of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209, USA.
Yazan S BatarsehDepartment of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209, USA.
Saeed AlqahtaniDepartment of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209, USA.
Baher IbrahimDepartment of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209, USA.
Harry LeVineSanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA.
Jeffrey N KellerPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70803, USA.
Amal KaddoumiDepartment of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209, USA. Electronic address: kaddoumi@ulm.edu.
University of Louisiana at Monroe · USPennington Biomedical Research Center · USUniversity of Kentucky · US

Funding

STABILITY' (symptomatic review during biologic therapy) Review in Inflammatory Bowel DiseaseP20GM103424 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI Seetharama D Jois · 2012 to 2026
$57.4M
NIGMS NIH HHS P20 GM103424
6 · The paper itself

Abstract

Extra-virgin olive oil (EVOO) is one of the main elements of Mediterranean diet. Several studies have suggested that EVOO has several health promoting effects that could protect from and decrease the risk of Alzheimer's disease (AD). In this study, we investigated the effect of consumption of EVOO-enriched diet on amyloid- and tau-related pathological alterations that are associated with the progression of AD and cerebral amyloid angiopathy (CAA) in TgSwDI mice. Feeding mice with EVOO-enriched diet for 6months, beginning at an age before amyloid-β (Aβ) accumulation starts, has significantly reduced total Aβ and tau brain levels with a significant improvement in mouse cognitive behavior. This reduction in brain Aβ was explained by the enhanced Aβ clearance pathways and reduced brain production of Aβ via modulation of amyloid-β precursor protein processing. On the other hand, although feeding mice with EVOO-enriched diet for 3months, beginning at an age after Aβ accumulation starts, showed improved clearance across the blood-brain barrier and significant reduction in Aβ levels, it did not affect tau levels or improve cognitive functions of TgSwDI mouse. Collectively, results of this study suggest that the long-term consumption of EVOO-containing diet starting at early age provides a protective effect against AD and its related disorder CAA.

Indexed as

Alzheimer DiseaseAmyloidAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsBlood-Brain BarrierBrainCerebral Amyloid AngiopathyCognitionDiet, MediterraneanDisease Models, AnimalHippocampusMaleMiceMice, TransgenicMicrocirculationAmyloidAmyloid beta-PeptidesAmyloid beta-Protein PrecursorMapt protein, mouseOlive Oiltau ProteinsAmyloid-βBlood–brain barrierClearanceExtra-virgin olive oilTau

Identifiers

PMID26344778
PMCPMC4679638
OpenAlexW1124117323

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.