ArticleCell reports2015
Calcium-Activated Potassium Channels at Nodes of Ranvier Secure Axonal Spike Propagation.
Article in Cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Robust activity-dependent mitochondrial calcium dynamics at the AIS is dispensable for action potential generation.The Journal of physiology · 2026Article
- Modulation of axon excitable domains by astrocytes and microglia.Frontiers in cellular neuroscience · 2025Review
- Nodal NaFrontiers in cellular neuroscience · 2025Article
- Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum.Nature communications · 2024Article
- Intrinsic organization of the corpus callosum.Frontiers in physiology · 2024Review
- Deconstructing the modular organization and real-time dynamics of mammalian spinal locomotor networks.Nature communications · 2023Article
- Parvalbumin basket cell myelination accumulates axonal mitochondria to internodes.Nature communications · 2022Article
- Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window.Nature communications · 2022Article
- Ion Channel Partnerships: Odd and Not-So-Odd Couples Controlling Neuronal Ion Channel Function.International journal of molecular sciences · 2022Review
- Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination.Nature communications · 2021Article
- Analog transmission of action potential fine structure in spiral ganglion axons.Journal of neurophysiology · 2021Article
- Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function.Nature communications · 2021Article
- Voltage-Gated Potassium Channels Ensure Action Potential Shape Fidelity in Distal Axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Functional Microstructure of CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The Molecular Basis for the Calcium-Dependent Slow Afterhyperpolarization in CA1 Hippocampal Pyramidal Neurons.Frontiers in physiology · 2021Review
- Assembly and Function of the Juxtaparanodal Kv1 Complex in Health and Disease.Life (Basel, Switzerland) · 2020Review
- Nodes of Ranvier during development and repair in the CNS.Nature reviews. Neurology · 2020Review
- CaeLife · 2020Article
- Influence of spatially segregated IPProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Functional connectivity between brain regions relies on long-range signaling by myelinated axons. This is secured by saltatory action potential propagation that depends fundamentally on sodium channel availability at nodes of Ranvier. Although various potassium channel types have been anatomically localized to myelinated axons in the brain, direct evidence for their functional recruitment in maintaining node excitability is scarce. Cerebellar Purkinje cells provide continuous input to their targets in the cerebellar nuclei, reliably transmitting axonal spikes over a wide range of rates, requiring a constantly available pool of nodal sodium channels. We show that the recruitment of calcium-activated potassium channels (IK, K(Ca)3.1) by local, activity-dependent calcium (Ca(2+)) influx at nodes of Ranvier via a T-type voltage-gated Ca(2+) current provides a powerful mechanism that likely opposes depolarizing block at the nodes and is thus pivotal to securing continuous axonal spike propagation in spontaneously firing Purkinje cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.