Evidence map›Paper›PMID 26344727›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2016

Functional and high-resolution retinal imaging monitoring photoreceptor damage in acute macular neuroretinopathy.

Isabelle Audo, Kiyoko Gocho, Florence Rossant, Saddek Mohand-Saïd, Kevin Loquin, Isabelle Bloch, José-Alain Sahel, Michel Paques

Registry-linked trialAbstract readCase Reports
PubMed Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01546181 (Observational, Follow-up Study of Adaptive Optics Retinal Imaging in Controls and During Retinal or General Diseases), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01546181 completednot on this map

Observational, Follow-up Study of Adaptive Optics Retinal Imaging in Controls and During Retinal or General Diseases

TypeobservationalSponsorInstitut National de la Santé Et de la Recherche Médicale, FranceRan2010 to 2017Enrolled256ConditionsRetinal Dystrophies, Age-related Macular Degeneration, Arterial Hypertension, Diabetes
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Ultra-high-resolution imaging of acute macular neuroretinopathy: a case report.American journal of ophthalmology case reports · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Isabelle AudoCentre Hospitalier National d'Ophtalmologie des Quinze-Vingts, DHU View Maintain, INSERM-DHOS CIC 1423, Paris, 75012, France. isabelle.audo@inserm.fr.
Kiyoko GochoCentre Hospitalier National d'Ophtalmologie des Quinze-Vingts, DHU View Maintain, INSERM-DHOS CIC 1423, Paris, 75012, France.
Florence RossantInstitut Supérieur d'Electronique de Paris, Paris, France.
Saddek Mohand-SaïdCentre Hospitalier National d'Ophtalmologie des Quinze-Vingts, DHU View Maintain, INSERM-DHOS CIC 1423, Paris, 75012, France.
Kevin LoquinFondation Ophtalmologique Adolphe de Rothschild, Paris, France.
Isabelle BlochTelecom Paris Tech, CNRS LTCI, Paris, France.
José-Alain SahelCentre Hospitalier National d'Ophtalmologie des Quinze-Vingts, DHU View Maintain, INSERM-DHOS CIC 1423, Paris, 75012, France.
Michel PaquesCentre Hospitalier National d'Ophtalmologie des Quinze-Vingts, DHU View Maintain, INSERM-DHOS CIC 1423, Paris, 75012, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo report functional and high-resolution retinal imaging abnormalities, including adaptive optics (AO) throughout the course of acute macular neuroretinopathy (AMNR).

methodsTwo female patients (four eyes) with a diagnosis of AMNR were observed at the Clinical Investigation Center, CHNO des Quinze-Vingts, Paris, France. The patients underwent detailed ophthalmic examination including best-corrected visual acuity, slit-lamp examination, kinetic and static perimetry, full-field and multifocal electroretinogram, infrared reflectance, autofluorescence imaging and spectral-domain optical coherence tomography (SD-OCT) and AO fundus imaging at presentation and during follow-up.

resultsBoth cases showed concomitant loss of integrity of the outer retinal structures on SD-OCT, and marked abnormalities on AO imaging with disruption of the visibility of the cone mosaic. In the first case, photoreceptor damage was seen to progress during several weeks before healing. In both cases, there were persistent morphological abnormalities of photoreceptors 1 year after onset.

conclusionThis study further highlights the value of AO fundus imaging to facilitate detection, mapping, and monitoring of damage to the cone outer segments during AMNR. In particular, residual damage to the cone mosaic can be precisely documented.

Indexed as

Acute DiseaseAdolescentDiagnostic ImagingElectroretinographyFemaleFluorescein AngiographyHumansPhotoreceptor Cells, VertebrateRetinal DiseasesScotomaTomography, Optical CoherenceVisual AcuityYoung AdultAcute macular neuroretinopathyAdaptive opticsHigh-resolution retinal imagingMultimodal retinal imagingSD-OCT

Identifiers

PMID26344727

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.