Evidence map›Paper›PMID 26344696›Full record

ArticleNature chemical biology2015

A biomimetic approach for enhancing the in vivo half-life of peptides.

Sravan C Penchala, Mark R Miller, Arindom Pal, Jin Dong, Nikhil R Madadi, Jinghang Xie, Hyun Joo, Jerry Tsai, Patrick Batoon, Vyacheslav Samoshin and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature chemical biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 134 citations in OpenAlex.

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  18. Development and Preclinical Evaluation of [Pharmaceuticals (Basel, Switzerland) · 2023
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Sravan C PenchalaDepartment of Pharmaceutics &Medicinal Chemistry, Thomas J. Long School of Pharmacy &Health Sciences, University of the Pacific, Stockton, California, USA.
Mark R MillerDepartment of Pharmaceutics &Medicinal Chemistry, Thomas J. Long School of Pharmacy &Health Sciences, University of the Pacific, Stockton, California, USA.
Arindom PalDepartment of Pharmaceutics &Medicinal Chemistry, Thomas J. Long School of Pharmacy &Health Sciences, University of the Pacific, Stockton, California, USA.
Jin DongDepartment of Pharmaceutics &Medicinal Chemistry, Thomas J. Long School of Pharmacy &Health Sciences, University of the Pacific, Stockton, California, USA.
Nikhil R MadadiDepartment of Pharmaceutics &Medicinal Chemistry, Thomas J. Long School of Pharmacy &Health Sciences, University of the Pacific, Stockton, California, USA.
Jinghang XieDepartment of Pharmaceutics &Medicinal Chemistry, Thomas J. Long School of Pharmacy &Health Sciences, University of the Pacific, Stockton, California, USA.
Hyun JooDepartment of Chemistry, University of the Pacific, Stockton, California, USA.
Jerry TsaiDepartment of Chemistry, University of the Pacific, Stockton, California, USA.
Patrick BatoonDepartment of Chemistry, University of the Pacific, Stockton, California, USA.
Vyacheslav SamoshinDepartment of Chemistry, University of the Pacific, Stockton, California, USA.
Andreas FranzDepartment of Chemistry, University of the Pacific, Stockton, California, USA.
Trever CoxDepartment of Pharmaceutics &Medicinal Chemistry, Thomas J. Long School of Pharmacy &Health Sciences, University of the Pacific, Stockton, California, USA.
Jesse MilesDepartment of Pharmaceutics &Medicinal Chemistry, Thomas J. Long School of Pharmacy &Health Sciences, University of the Pacific, Stockton, California, USA.
William K ChanDepartment of Pharmaceutics &Medicinal Chemistry, Thomas J. Long School of Pharmacy &Health Sciences, University of the Pacific, Stockton, California, USA.
Miki S ParkDepartment of Pharmaceutics &Medicinal Chemistry, Thomas J. Long School of Pharmacy &Health Sciences, University of the Pacific, Stockton, California, USA.
Mamoun M AlhamadshehDepartment of Pharmaceutics &Medicinal Chemistry, Thomas J. Long School of Pharmacy &Health Sciences, University of the Pacific, Stockton, California, USA.
University of the Pacific · US

Funding

Harnessing transthyretin to extend the in vivo half-life of therapeutic peptidesR15GM110677 · NIGMS · UNIVERSITY OF THE PACIFIC-STOCKTON · PI ALHAMADSHEH, MAMOUN M · 2014 to 2014
$299k
NIGMS NIH HHS 1R15GM110677-01NIGMS NIH HHS R15 GM110677
6 · The paper itself

Abstract

The tremendous therapeutic potential of peptides has not yet been realized, mainly owing to their short in vivo half-life. Although conjugation to macromolecules has been a mainstay approach for enhancing protein half-life, the steric hindrance of macromolecules often harms the binding of peptides to target receptors, compromising the in vivo efficacy. Here we report a new strategy for enhancing the in vivo half-life of peptides without compromising their potency. Our approach involves endowing peptides with a small molecule that binds reversibly to the serum protein transthyretin. Although there are a few molecules that bind albumin reversibly, we are unaware of designed small molecules that reversibly bind other serum proteins and are used for half-life extension in vivo. We show here that our strategy was effective in enhancing the half-life of an agonist for GnRH receptor while maintaining its binding affinity, which was translated into superior in vivo efficacy.

Indexed as

Amino Acid SequenceAnimalsBenzoatesBenzoic AcidBinding SitesBiomimeticsCell SurvivalHalf-LifeHeLa CellsHumansLigandsMaleMicrosomes, LiverModels, MolecularMolecular Docking SimulationMolecular Sequence DataacoramidisBenzoatesBenzoic AcidLigandsPeptide FragmentsPrealbuminPyrazolesReceptors, LHRH

Identifiers

PMID26344696
PMCPMC4575266
OpenAlexW2126818728

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.