Evidence map›Paper›PMID 26343985›Full record

ArticleThe Journal of urology2016

The Comparative Harms of Open and Robotic Prostatectomy in Population Based Samples.

Brock O'Neil, Tatsuki Koyama, JoAnn Alvarez, Ralph M Conwill, Peter C Albertsen, Matthew R Cooperberg, Michael Goodman, Sheldon Greenfield, Ann S Hamilton, Karen E Hoffman and 10 more

Open access · greenAbstract readComparative StudyMulticenter Study
In one paragraph

Article in The Journal of urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Robotic-assistedTranslational andrology and urology · 2018
    Article
  14. Observational
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Postprostatectomy Erectile Dysfunction: A Review.The world journal of men's health · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 13 institutions in 1 country.

Brock O'NeilDepartment of Urologic Surgery, Vanderbilt University, Nashville, Tennessee. Electronic address: brock.oneil@vanderbilt.edu.
Tatsuki KoyamaDepartment of Biostatistics, Vanderbilt University, Nashville, Tennessee.
JoAnn AlvarezDepartment of Biostatistics, Vanderbilt University, Nashville, Tennessee.
Ralph M ConwillCEASAR Patient Advocacy Network.
Peter C AlbertsenDivision of Urology, University of Connecticut Health Center, Farmington, Connecticut.
Matthew R CooperbergDepartment of Urology, University of California San Francisco, San Francisco.
Michael GoodmanDepartment of Epidemiology, Emory University, Atlanta, Georgia.
Sheldon GreenfieldDepartment of Medicine, University of California, Irvine, Irvine.
Ann S HamiltonDepartment of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Karen E HoffmanDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Richard M HoffmanDivision of General Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Sherrie H KaplanDepartment of Medicine, University of California, Irvine, Irvine.
Janet L StanfordDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Antoinette M StroupNew Jersey State Cancer Registry, Trenton, New Jersey.
Lisa E PaddockNew Jersey State Cancer Registry, Trenton, New Jersey.
Xiao-Cheng WuLouisiana State University Health Sciences Center, New Orleans, Louisiana.
Robert A StephensonDivision of Urology, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
Matthew J ResnickDepartment of Urologic Surgery, Vanderbilt University, Nashville, Tennessee; Geriatric Research Education and Clinical Center, VA Tennessee Valley Healthcare System, Nashville, Tennessee.
Daniel A BarocasDepartment of Urologic Surgery, Vanderbilt University, Nashville, Tennessee.
David F PensonDepartment of Urologic Surgery, Vanderbilt University, Nashville, Tennessee; Geriatric Research Education and Clinical Center, VA Tennessee Valley Healthcare System, Nashville, Tennessee.
Vanderbilt University · USUniversity of California, Irvine · USEmory University · USFred Hutch Cancer Center · USHuntsman Cancer Institute · USLouisiana State University Health Sciences Center New Orleans · USPatient Advocate Foundation · USThe University of Texas MD Anderson Cancer Center · USUConn Health · USUniversity of California, San Francisco · USUniversity of Iowa · USUniversity of Southern California · USVA Tennessee Valley Healthcare System · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
Comparative Effectiveness of Treatments for Localized Prostate CancerR01HS019356 · AHRQ · VANDERBILT UNIVERSITY · PI PENSON, DAVID F. · 2010 to 2010
$7.6M
SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAMN01PC067009 · PC · FRED HUTCHINSON CANCER RESEARCH CENTER · PI THOMAS, DAVID B · 1996 to 2000
$3.0M
SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAMN01PC067007 · PC · UNIVERSITY OF NEW MEXICO · PI KEY, CHARLES R · 1996 to 2000
$2.4M
SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAMN01PC067010 · PC · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROSS, RONALD K · 1996 to 2000
$2.4M
SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAMN01PC067005 · PC · CONNECTICUT STATE DEPT OF PUBLIC HEALTH · PI POLEDNAK, ANTHONY · 1996 to 2000
$1.9M
Comparative Effectiveness of Modern Therapies for Localized Prostate CancerR01HS022640 · AHRQ · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PENSON, DAVID F. · 2013 to 2013
$1.8M
SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAMN01PC067006 · PC · EMORY UNIVERSITY · PI YOUNG, JOHN L · 1996 to 2000
$1.7M
Race, Comorbidity & Long Term Prostate Cancer OutcomesR01CA114524 · NCI · VANDERBILT UNIVERSITY · PI PENSON, DAVID F. · 2007 to 2009
$1.7M
SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAMN01PC067000 · PC · UNIVERSITY OF UTAH · PI WIGGINS, CHARLES L · 1996 to 2000
$1.3M
AHRQ HHS 1R01HS019356AHRQ HHS 1R01HS022640-01AHRQ HHS R01 HS019356AHRQ HHS R01 HS022640NCI NIH HHS N01 PC067006NCI NIH HHS N01 PC067009NCI NIH HHS N01 PC067010NCI NIH HHS N01-PC-67000NCI NIH HHS N01-PC-67005NCI NIH HHS N01-PC-67006NCI NIH HHS N01-PC-67007NCI NIH HHS N01-PC-67009NCI NIH HHS R01 CA114524NCI NIH HHS R01-CA114524
6 · The paper itself

Abstract

purposeRobotic assisted radical prostatectomy has largely replaced open radical prostatectomy for the surgical management of prostate cancer despite conflicting evidence of superiority with respect to disease control or functional sequelae. Using population cohort data, in this study we examined sexual and urinary function in men undergoing open radical prostatectomy vs those undergoing robotic assisted radical prostatectomy. MATERIALS AND

methodsSubjects surgically treated for prostate cancer were selected from 2 large population based prospective cohort studies, the Prostate Cancer Outcomes Study (enrolled 1994 to 1995) and the Comparative Effectiveness Analysis of Surgery and Radiation (enrolled 2011 to 2012). Subjects completed baseline, 6-month and 12-month standardized patient reported outcome measures. Main outcomes were between-group differences in functional outcome scores at 6 and 12 months using linear regression, and adjusting for baseline function, sociodemographic and clinical characteristics. Sensitivity analyses were used to evaluate outcomes between patients undergoing open radical prostatectomy and robotic assisted radical prostatectomy within and across CEASAR and PCOS.

resultsThe combined cohort consisted of 2,438 men, 1,505 of whom underwent open radical prostatectomy and 933 of whom underwent robotic assisted radical prostatectomy. Men treated with robotic assisted radical prostatectomy reported better urinary function at 6 months (mean difference 3.77 points, 95% CI 1.09-6.44) but not at 12 months (1.19, -1.32-3.71). Subjects treated with robotic assisted radical prostatectomy also reported superior sexual function at 6 months (8.31, 6.02-10.56) and at 12 months (7.64, 5.25-10.03). Sensitivity analyses largely supported the sexual function findings with inconsistent support for urinary function results.

conclusionsThis population based study reveals that men undergoing robotic assisted radical prostatectomy likely experience less decline in early urinary continence and sexual function than those undergoing open radical prostatectomy. The clinical meaning of these differences is uncertain and longer followup will be required to establish whether these benefits are durable.

Indexed as

AgedHumansMaleMiddle AgedPostoperative ComplicationsProspective StudiesProstatectomyProstatic NeoplasmsRobotic Surgical ProceduresSEER ProgramTreatment OutcomeUnited Statespatient outcome assessmentprostatectomyrobotics

Identifiers

PMID26343985
PMCPMC4916911
OpenAlexW1264177899

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.