ArticleNeurobiology of learning and memory2015
Phasic dopamine release induced by positive feedback predicts individual differences in reversal learning.
Article in Neurobiology of learning and memory, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Dopamine Dynamics in the Nucleus Accumbens Reflect Confidence in Detecting the Occurrence and Nonoccurrence of Visual Signals in Perceptual Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The long-term associations of childhood parental loss with attachment, creativity, and epigenetic regulation.Scientific reports · 2025Article
- Effects of chronic stress on cognitive function - From neurobiology to intervention.Neurobiology of stress · 2024Review
- A narrative on the neurobiological roots of attachment-system functioning.Communications psychology · 2024Review
- Characterization of striatal dopamine projections across striatal subregions in behavioral flexibility.The European journal of neuroscience · 2023Article
- Article
- Cognitive flexibility assessment with a new Reversal learning task paradigm compared with the Wisconsin card sorting test exploring the moderating effect of gender and stress.Psychological research · 2023Article
- An Open-Source Platform for Head-Fixed Operant and Consummatory Behavior.bioRxiv : the preprint server for biology · 2023Article
- Dopamine Circuit Mechanisms of Addiction-Like Behaviors.Frontiers in neural circuits · 2021Review
- Dopamine modulates individual differences in avoidance behavior: A pharmacological, immunohistochemical, neurochemical and volumetric investigation.Neurobiology of stress · 2020Article
- Potent Dopamine D2 Antagonists Block the Reward-Enhancing Effects of Nicotine in Smokers With Schizophrenia.Schizophrenia bulletin · 2019Article
- Striatum-related functional activation during reward- versus punishment-based learning in psychosis risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Contributions of nucleus accumbens dopamine to cognitive flexibility.The European journal of neuroscience · 2019Article
- Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat: behavioural and computational evidence.Psychopharmacology · 2019Article
- Mesolimbic dopamine projections mediate cue-motivated reward seeking but not reward retrieval in rats.eLife · 2019Article
- NMDA receptor deletion on dopamine neurons disrupts visual discrimination and reversal learning.Neuroscience letters · 2019Article
- Reversal Learning Performance in the XYFrontiers in behavioral neuroscience · 2019Article
- Translational tests involving non-reward: methodological considerations.Psychopharmacology · 2019Review
- Latency to Reward Predicts Social Dominance in Rats: A Causal Role for the Dopaminergic Mesolimbic System.Frontiers in behavioral neuroscience · 2019Article
- Prefrontal cortex executive processes affected by stress in health and disease.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Striatal dopamine (DA) is central to reward-based learning. Less is known about the contribution of DA to the ability to adapt previously learned behavior in response to changes in the environment, such as a reversal of response-reward contingencies. We hypothesized that DA is involved in the rapid updating of response-reward information essential for successful reversal learning. We trained rats to discriminate between two levers, where lever availability was signaled by a non-discriminative cue. Pressing one lever was always rewarded, whereas the other lever was never rewarded. After reaching stable discrimination performance, a reversal was presented, so that the previously non-rewarded lever was now rewarded and vice versa. We used fast-scan cyclic voltammetry to monitor DA release in the ventromedial striatum. During discrimination performance (pre-reversal), cue presentation induced phasic DA release, whereas reward delivery did not. The opposite pattern was observed post-reversal: Striatal DA release emerged after reward delivery, while cue-induced release diminished. Trial-by-trial analysis showed rapid reinstatement of cue-induced DA release on trials immediately following initial correct responses. This effect of positive feedback was observed in animals that learned the reversal, but not in 'non-learners'. In contrast, neither pre-reversal responding and DA signaling, nor post-reversal DA signaling in response to negative feedback differed between learners and non-learners. Together, we show that phasic DA dynamics in the ventromedial striatum encoding reward-predicting cues are associated with positive feedback during reversal learning. Furthermore, these signals predict individual differences in learning that are not present prior to reversal, suggesting a distinct role for dopamine in the adaptation of previously learned behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.