Evidence map›Paper›PMID 26343804›Full record

ArticleInternational journal of geriatric psychiatry2016

Apolipoprotein E and Clusterin can magnify effects of personality vulnerability on declarative memory performance in non-demented older adults.

Shraddha Sapkota, Sandra A Wiebe, Brent J Small, Roger A Dixon

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of geriatric psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Shraddha SapkotaNeuroscience and Mental Health Institute, University of Alberta, Edmonton, Canada.
Sandra A WiebeNeuroscience and Mental Health Institute, University of Alberta, Edmonton, Canada.
Brent J SmallSchool of Aging Studies, University of South Florida, Tampa, FL, USA.
Roger A DixonNeuroscience and Mental Health Institute, University of Alberta, Edmonton, Canada.
University of Alberta · CAUniversity of South Florida · USWomen and Children’s Health Research Institute · CA

Funding

LONGITUDINAL STUDY OF COGNITIVE AGINGR01AG008235 · NIA · UNIVERSITY OF VICTORIA · PI DIXON, ROGER A · 1989 to 2017
$2.3M
NIA NIH HHS R01 AG008235
6 · The paper itself

Abstract

objectivesRecent research has linked psychological (personality) factors and specific genetic risk polymorphisms to performance on neurocognitive phenotypes. We examined whether episodic or semantic memory performance is associated with (a) three personality traits (i.e. neuroticism, extraversion, and openness to experience), (b) two neurodegenerative-related polymorphisms (i.e. Apolipoprotein E (APOE; rs7412; rs429358), Clusterin (CLU; rs11136000)), and (c) cross-domain risk interactions (magnification effects).

methodsLinear growth models were examined to test independent associations between personality traits and declarative memory performance, and potential interaction effects with APOE and CLU genetic risk. Normal older adults (n = 282) with personality and genetic data from the Victoria Longitudinal Study were included at baseline and for up to 14 years of follow-up.

resultsFirst, we observed that higher openness to experience levels were associated with better episodic and semantic memory. Second, three significant gene × personality interactions were associated with poorer memory performance at baseline. These synergistic effects are: (a) APOE allelic risk (ε4+) carriers with lower openness to experience levels, (b) CLU (no risk: T/T) homozygotes with higher extraversion levels, and (c) CLU (no risk: T/T) homozygotes with lower neuroticism levels.

conclusionsSpecific neurodegenerative-related genetic polymorphisms (i.e. APOE and CLU) moderate and magnify the risk contributed by selected personality trait levels (i.e. openness to experience, extraversion) on declarative memory performance in non-demented aging. Future research could target interactions of other personality traits and genetic polymorphisms in different clinical populations to predict other neurocognitive deficits or transitions to cognitive impairment and dementia.

Indexed as

AdultAgedAgingAnxiety DisordersApolipoproteins EClusterinExtraversion, PsychologicalFemaleHumansLinear ModelsLongitudinal StudiesMaleMemoryMemory, EpisodicMiddle AgedNeurodegenerative DiseasesApolipoproteins EClusterinApolipoprotein EClusteringenetic riskmemorypersonality traitsVictoria Longitudinal Study

Identifiers

PMID26343804
PMCPMC4826141
OpenAlexW1867105334

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.