ArticleJournal of psychiatric research2015
Decision-making under uncertainty in obsessive-compulsive disorder.
Article in Journal of psychiatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Systematic Review of the Positive Valence System in Autism Spectrum Disorder.Neuropsychology review · 2021Pooled it
- Common and distinct brain activity associated with risky and ambiguous decision-making.Drug and alcohol dependence · 2020Pooled it
- Altered social and cognitive control interactions during decision-making in social anxiety.Psychological medicine · 2026Article
- Threading the Needle: Practical Considerations for Merging Theory-Driven Computational Psychiatry With Data-Driven Analytics to Enhance Precision Health at Scale.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Review
- Largely Intact But Less Reliable and Distributed Neural Representations of Subjective Value in Human Opioid Addiction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The metacognitive paradox of OCD: confidence is globally reduced but shows increased sensitivity to local evidence.Research square · 2025Article
- Altered Reward Processing in Obsessive-Compulsive Disorder: Insights From Active and Observational Learning.Psychophysiology · 2025Article
- Risk-aversion with both high and low ambiguity: Elevated OCD symptom severity and intolerance of uncertainty are associated with less risk-taking in an OCD patient sub-sample.Journal of obsessive-compulsive and related disorders · 2025Article
- Decision-making using the Iowa gambling test in unaffected first-degree relatives of obsessive-compulsive disorder: Comparison with healthy controls and patients with obsessive-compulsive disorder.Journal of neuropsychology · 2025Article
- Delay Discounting and Risk Tolerance in Obsessive Compulsive Disorder: Results From the Global OCD Study.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Understanding learning through uncertainty and bias.Communications psychology · 2025Review
- A comprehensive evaluation of the neurocognitive predictors of problematic alcohol use, eating, pornography, and internet use: A 6-month longitudinal study.Journal of behavioral addictions · 2024Article
- Examining relationships among NODDI indices of white matter structure in prefrontal cortical-thalamic-striatal circuitry and OCD symptomatology.Translational psychiatry · 2024Article
- Article
- Large environmental changes reduce valence-dependent belief updating.Scientific reports · 2024Article
- Transdiagnostic Anxiety-Related Increases in Information Sampling are Associated With Altered Valuation.Computational psychiatry (Cambridge, Mass.) · 2024Article
- Cognitive inflexibility, obsessive-compulsive symptoms and traits and poor post-pandemic adjustment.Neuroscience applied · 2024Review
- Feeling uncertain despite knowing the risk: Patients with OCD (but not controls) experience known and unknown probabilistic decisions as similarly distressing and uncertain.Journal of obsessive-compulsive and related disorders · 2023Article
- Intolerance of Uncertainty as a Cognitive Vulnerability for Obsessive-Compulsive Disorder: A Qualitative Review.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2023Article
- Microbial Reprogramming in Obsessive-Compulsive Disorders: A Review of Gut-Brain Communication and Emerging Evidence.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Obsessive compulsive disorder (OCD) produces profound morbidity. Difficulties with decision-making and intolerance of uncertainty are prominent clinical features in many patients. The nature and etiology of these deficits are poorly understood. We used a well-validated choice task, grounded in behavioral economic theory, to investigate differences in valuation and value-based choice during decision making under uncertainty in 20 unmedicated participants with OCD and 20 matched healthy controls. Participants' choices were used to assess individual decision-making characteristics. OCD participants did not differ from healthy controls in how they valued uncertain options when outcome probabilities were known (risk) but were more likely than healthy controls to avoid uncertain options when these probabilities were imprecisely specified (ambiguity). Compared to healthy controls, individuals with OCD were less consistent in their choices and less able to identify options that should be clearly preferable. These abnormalities correlated with symptom severity. These results suggest that value-based choices during decision-making are abnormal in OCD. Individuals with OCD show elevated intolerance of uncertainty, but only when outcome probabilities are themselves uncertain. Future research focused on the neural valuation network, which is implicated in value-based computations, may provide new neurocognitive insights into the pathophysiology of OCD. Deficits in decision-making processes may represent a target for therapeutic intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.