ArticleJournal of psychiatric research2015
Morphometric analysis of amygdla and hippocampus shape in impulsively aggressive and healthy control subjects.
Article in Journal of psychiatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comprehensive Review and Meta-Analysis of Psychological and Pharmacological Treatment for Intermittent Explosive Disorder: Insights From Both Case Studies and Randomized Controlled Trials.Clinical psychology & psychotherapyPooled it
- Lesion network mapping of focal injury-related aggression finds two distinct network injury patterns.Brain communications · 2026Article
- Corticolimbic Structural Deficits in Violent Patients with Schizophrenia.Brain sciences · 2025Article
- Distinct patterns of hippocampal subfield volumes predict coping strategies, emotion regulation, and impulsivity in healthy adults.Brain imaging and behavior · 2024Article
- Trait Impulsivity as a Feature of Parkinson's Disease Treatment and Progression.Parkinson's disease · 2024Review
- Neurobiology of Aggression-Review of Recent Findings and Relationship with Alcohol and Trauma.Biology · 2023Review
- Effects of childhood trauma on aggressive behaviors and hippocampal function: the modulation of COMT haplotypes.Psychoradiology · 2023Article
- Prevalence and psychiatric comorbidities of intermittent explosive disorders in Metropolitan São Paulo, Brazil.Social psychiatry and psychiatric epidemiology · 2021Article
- Understanding Brain Mechanisms of Reactive Aggression.Current psychiatry reports · 2020Review
- Family Income Mediates the Effect of Parental Education on Adolescents' Hippocampus Activation During an N-Back Memory Task.Brain sciences · 2020Article
- Peripubertal stress-induced heightened aggression: modulation of the glucocorticoid receptor in the central amygdala and normalization by mifepristone treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Emerging roles of Fgf14 in behavioral control.Behavioural brain research · 2019Article
- Genome-Wide DNA Methylation Changes Associated with Intermittent Explosive Disorder: A Gene-Based Functional Enrichment Analysis.The international journal of neuropsychopharmacology · 2018Article
- Olfactory Processing in Male Children with Autism: Atypical Odor Threshold and Identification.Journal of autism and developmental disorders · 2017Article
Corrections and comments
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5 authors.
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Abstract
backgroundImpulsive aggressive behavior is thought to be facilitated by activation of the limbic brain, particularly the amygdala and hippocampus., Functional imaging studies suggest abnormalities in limbic brain activity during emotional information processing in impulsively aggressive subjects with Intermittent Explosive Disorder (IED). It is not known if IED is associated with altered amygdala and hippocampus volume and shape.
methodsWe examined the volume and shape of the amygdala-hippocampal complex, using morphometric analysis of high resolution structural 3T MR scans in healthy control (HC: n = 73) subjects without history of Axis I or II psychiatric conditions and in subjects with IED (n = 67).
resultsWhile no volume differences were observed between HC and IED subjects, a significant level of morphometric deformation, suggestive of cell loss, in both amygdala and hippocampal structures was observed bilaterally in IED subjects. Analysis of a canonical variable that used the first 10 eigenvectors from both sides of the brain revealed that these morphometric deformations in the IED subjects were not due the presence of confounding variables or to comorbidities among IED subjects.
conclusionsThese data reveal that IED is associated with a significant loss of neurons in both the amygdala and hippocampus. These changes may play a role in the functional abnormalities observed in previous fMRI studies and in the pathophysiology of impulsive aggressive behavior.
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