ReviewJournal of neuroscience methods2016
In vivo models of cortical acquired epilepsy.
Review in Journal of neuroscience methods, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Preoptic area influences sleep-related seizures in a genetic epilepsy mouse model.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Network effects of traumatic brain injury: from infra slow to high frequency oscillations and seizures.Journal of computational neuroscience · 2025Article
- Sleep, oscillations, and epilepsy.Epilepsia · 2023Article
- Review
- Sleep slow-wave oscillations trigger seizures in a genetic epilepsy model of Dravet syndrome.Brain communications · 2023Article
- Repeated applications of high potassium elicit long-term changes in a motor circuit from the crab,iScience · 2022Article
- Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions.Pharmacological reviews · 2022Review
- Autonomic dysfunction in epilepsy mouse models with implications for SUDEP research.Frontiers in neurology · 2022Review
- Injecting Information into the Mammalian Cortex: Progress, Challenges, and Promise.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2021Review
- Application of Optogenetics in Epilepsy Research.Advances in experimental medicine and biology · 2021Article
- Partial Activation of TrkB Receptors Corrects Interneuronal Calcium Channel Dysfunction and Reduces Epileptogenic Activity in Neocortex following Injury.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Rapid adaptation to elevated extracellular potassium in the pyloric circuit of the crab,Journal of neurophysiology · 2020Article
- Dissecting the genetic basis of comorbid epilepsy phenotypes in neurodevelopmental disorders.Genome medicine · 2019Article
- Ionic and synaptic mechanisms of seizure generation and epileptogenesis.Neurobiology of disease · 2019Review
- Novel Optogenetic Approaches in Epilepsy Research.Frontiers in neuroscience · 2019Review
- Gabapentin Prevents Progressive Increases in Excitatory Connectivity and Epileptogenesis Following Neocortical Trauma.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Rapamycin provides anti-epileptogenic effect in a rat model of post-traumatic epilepsy via deactivation of mTOR signaling pathway.Experimental and therapeutic medicine · 2018Article
- Structural alterations in fast-spiking GABAergic interneurons in a model of posttraumatic neocortical epileptogenesis.Neurobiology of disease · 2017Article
- Susceptibility to hippocampal kindling seizures is increased in aging C57 black mice.IBRO reports · 2017Article
- A versatile optical tool for studying synaptic GABAJournal of cell science · 2017Article
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Authors and funding
4 authors.
Funding
Abstract
The neocortex is the site of origin of several forms of acquired epilepsy. Here we provide a brief review of experimental models that were recently developed to study neocortical epileptogenesis as well as some major results obtained with these methods. Most of neocortical seizures appear to be nocturnal and it is known that neuronal activities reveal high levels of synchrony during slow-wave sleep. Therefore, we start the review with a description of mechanisms of neuronal synchronization and major forms of synchronized normal and pathological activities. Then, we describe three experimental models of seizures and epileptogenesis: ketamine-xylazine anesthesia as feline seizure triggered factor, cortical undercut as cortical penetrating wound model and neocortical kindling. Besides specific technical details describing these models we also provide major features of pathological brain activities recorded during epileptogenesis and seizures. The most common feature of all models of neocortical epileptogenesis is the increased duration of network silent states that up-regulates neuronal excitability and eventually leads to epilepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.