ArticleDevelopmental cell2015
Co-option of an Ancestral Hox-Regulated Network Underlies a Recently Evolved Morphological Novelty.
Article in Developmental cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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62 citing papers in PubMed.
- The genomic origins and evolutionary path to a key innovation in the world's most venomous snakes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Metabolic and developmental rate divergence between serially homologous cells underlies an evolutionary innovation in Drosophila.PLoS biology · 2026Article
- The genomic origins and evolutionary path to a key innovation in the world's most venomous snakes.bioRxiv : the preprint server for biology · 2026Article
- Heat-mediated manipulation of gene expression by IR-LEGO in the developing genitalia in Drosophila.G3 (Bethesda, Md.) · 2026Article
- Trait-specific chromatin architectures channel pleiotropic genes toward sexually dimorphic development in horned beetles.bioRxiv : the preprint server for biology · 2026Article
- Phenotypic complexity determines the predictability of molecular convergence.bioRxiv : the preprint server for biology · 2026Article
- Morphological innovation without gene co-option: thebioRxiv : the preprint server for biology · 2026Article
- Parallels in the regulatory landscape of dimorphic female and male genital structures in Drosophila melanogaster.Genetics · 2026Article
- Shared regulatory networks link vein positioning and eyespot ring formation in butterflies.Communications biology · 2025Article
- A Notch signal required for a morphological novelty inScience advances · 2025Article
- Genome Mountaineering: Expanding Horizons of the 3D Genome for the Intrepid Evolutionary Adventurer.Genome biology and evolution · 2025Review
- Evolution: Gene reuse… again!Current biology : CB · 2025Article
- Quantifying Transcriptome Turnover on Phylogenies by Modeling Gene Expression as a Binary Trait.Molecular biology and evolution · 2025Article
- Recent approaches lead to a deeper understanding of diverse segmentation mechanisms in insects, with a focus on the pair-rule genes.Current opinion in insect science · 2025Review
- A shared developmental genetic basis for sexually antagonistic male and female adaptations in the toothed water strider.Evolution letters · 2025Article
- Co-option of the trichome-forming network initiated the evolution of a morphological novelty in Drosophila eugracilis.Current biology : CB · 2024Article
- De Novo Genes.Annual review of genetics · 2024Review
- A developmental atlas of male terminalia across twelve species ofFrontiers in cell and developmental biology · 2024Article
- Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty.Nature communications · 2023Article
- Resolving between novelty and homology in the rapidly evolving phallus of Drosophila.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2023Article
2 more citing papers are in PubMed but not listed here.
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8 authors.
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Abstract
The evolutionary origins of complex morphological structures such as the vertebrate eye or insect wing remain one of the greatest mysteries of biology. Recent comparative studies of gene expression imply that new structures are not built from scratch, but rather form by co-opting preexisting gene networks. A key prediction of this model is that upstream factors within the network will activate their preexisting targets (i.e., enhancers) to form novel anatomies. Here, we show how a recently derived morphological novelty present in the genitalia of D. melanogaster employs an ancestral Hox-regulated network deployed in the embryo to generate the larval posterior spiracle. We demonstrate how transcriptional enhancers and constituent transcription factor binding sites are used in both ancestral and novel contexts. These results illustrate network co-option at the level of individual connections between regulatory genes and highlight how morphological novelty may originate through the co-option of networks controlling seemingly unrelated structures.
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