ArticleCortex; a journal devoted to the study of the nervous system and behavior2015
Neuropsychiatric effects of neurodegeneration of the medial versus lateral ventral prefrontal cortex in humans.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
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- Left and right corticobasal syndrome: comparison of cognitive profiles between metabolic imaging - matched groups.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Automated brain segmentation and volumetry in dementia diagnostics: a narrative review with emphasis on FreeSurfer.Frontiers in aging neuroscience · 2024Review
- A transdiagnostic review of neuroimaging studies of apathy and disinhibition in dementia.Brain : a journal of neurology · 2022Review
- A Critical Review of Behavioral and Emotional Disinhibition.The Journal of nervous and mental disease · 2020Review
- Motivational Impairment is Accompanied by Corticoaccumbal Dysfunction in the BACHD-Tg5 Rat Model of Huntington's Disease.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Reduced Glutamate in the Medial Prefrontal Cortex Is Associated With Emotional and Cognitive Dysregulation in People With Chronic Pain.Frontiers in neurology · 2019Article
- The Association Between Distinct Frontal Brain Volumes and Behavioral Symptoms in Mild Cognitive Impairment, Alzheimer's Disease, and Frontotemporal Dementia.Frontiers in neurology · 2019Article
- Psychiatric symptoms in preclinical behavioural-variant frontotemporal dementia inJournal of neurology, neurosurgery, and psychiatry · 2018Article
- Neuropsychiatric disturbances in atypical parkinsonian disorders.Neuropsychiatric disease and treatment · 2018Review
- Modulating what is and what could have been: The effect of transcranial direct current stimulation on the evaluation of attained and unattained decision outcomes.Cognitive, affective & behavioral neuroscience · 2017Article
- Article
- Disentangling the genetic underpinnings of neuropsychiatric symptoms in Alzheimer's disease in the Alzheimer's Disease Sequencing Project: Study design and methodology.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Neuropsychiatric and behavioral symptom clusters in frontotemporal dementia.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Animal evidence suggests that a brain network involving the medial and rostral ventral prefrontal cortex (PFC) is central for threat response and arousal and a network involving the lateral and caudal PFC plays an important role in reward learning and behavioral control. In this study, we contrasted the neuropsychiatric effects of degeneration of the medial versus lateral PFC in 43 patients with Frontotemporal dementia (FTD) and 11 patients with Corticobasal Syndrome (CBS) using MRI, the Neuropsychiatric Inventory (NPI), and the Sorting, Tower, Twenty Questions, and Fluency tests of the Delis-Kaplan Executive Function System (D-KEFS). Deviations in MRI grey matter volume from 86 age-matched healthy control subjects were determined for the patients using FreeSurfer. Multivariate regression was used to determine which brain areas were associated with specific neuropsychiatric and cognitive symptoms. Decreased grey matter volume of the right medial ventral PFC was associated with increased anxiety and apathy, decreased volume of the right lateral ventral PFC with apathy and inappropriate repetitive behaviors, and of the left lateral ventral PFC with poor performance on the sorting and Twenty Questions task in patients with FTD and CBS. Similar to in animal studies, damage to the medial OFC appears to be associated with a disruption of arousal, and damage to the lateral OFC appears to be associated with deficits in trial-and-error learning and behavioral dysregulation. Studies of brain dysfunction in humans are valuable to bridge animal and human neuropsychiatric research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.