Evidence map›Paper›PMID 26343257›Full record

ArticleExperimental gerontology2015

Reduced rate of knee extensor torque development in older adults with knee osteoarthritis is associated with intrinsic muscle contractile deficits.

Damien M Callahan, Timothy W Tourville, James R Slauterbeck, Philip A Ades, Jennifer Stevens-Lapsley, Bruce D Beynnon, Michael J Toth

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental gerontology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01190046 (Muscle Disuse and Contractile Dysfunction in the Elderly), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01190046 nacompletednot on this map

Muscle Disuse and Contractile Dysfunction in the Elderly

TypeinterventionalSponsorUniversity of VermontRan2010 to 2016Enrolled35ConditionsOsteoarthritisArmsResistance exercise training
3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Damien M CallahanDepartment of Medicine, University of Vermont, College of Medicine, Burlington, VT, United States.
Timothy W TourvilleDepartment of Orthopaedics and Rehabilitation, University of Vermont, College of Medicine, Burlington, VT, United States.
James R SlauterbeckDepartment of Orthopaedics and Rehabilitation, University of Vermont, College of Medicine, Burlington, VT, United States.
Philip A AdesDepartment of Medicine, University of Vermont, College of Medicine, Burlington, VT, United States.
Jennifer Stevens-LapsleyDepartment of Physical Medicine and Rehabilitation, University of Colorado, Denver, CO, United States.
Bruce D BeynnonDepartment of Orthopaedics and Rehabilitation, University of Vermont, College of Medicine, Burlington, VT, United States.
Michael J TothDepartment of Medicine, University of Vermont, College of Medicine, Burlington, VT, United States; Department of Orthopaedics and Rehabilitation, University of Vermont, College of Medicine, Burlington, VT, United States; Department of Molecular Physiology and Biophysics, University of Vermont, College of Medicine, Burlington, VT, United States. Electronic address: michael.toth@uvm.edu.

Funding

POST-DOCTORAL CARDIOVASCULAR RESEARCH TRAINING PROGRAMT32HL007647 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI LEWINTER, MARTIN M · 1988 to 2013
$3.3M
Muscle disuse and contractile dysfunction in the elderlyR01AG033547 · NIA · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI TOTH, MICHAEL J · 2010 to 2014
$1.9M
NHLBI NIH HHS HL-007647NHLBI NIH HHS T32 HL007647NIA NIH HHS AG-033547NIA NIH HHS R01 AG033547
6 · The paper itself

Abstract

We examined the effect of knee osteoarthritis on the rate of torque development (RTD) of the knee extensors in older adults with advanced-stage knee osteoarthritis (OA; n=15) and recreationally-active controls (n=15) of similar age, sex and health status, as well as the relationship between RTD and the size and contractility of single muscle fibers. OA participants had lower RTD when expressed in absolute terms (Nm/ms). There were sex differences in peak RTD (P<0.05), with greater RTD in men, but no group by sex interaction effects for any variables. The lower RTD in OA versus controls was not explained by variation between groups in the fiber type admixture of the muscle, and was mitigated when RTD was normalized to peak torque (PT). In knee OA volunteers, we found strong correlations between the RTD expressed relative to PT and the velocity of contraction of single myosin heavy chain (MHC) I and IIA/X muscle fibers (r=0.652 and 0.862; both P<0.05) and power output of MHC I fibers (r=0.642; P<0.05). In controls, RTD relative to PT was related to fiber cross-sectional area of MHC IIA/X fibers (r=0.707; P<0.05), but not measures of single fiber contractile performance. To our knowledge, these results represent the first demonstration that variation in whole muscle contractile kinetics in patients with advanced-stage knee osteoarthritis and healthy older adults is related, in part, to the size and function of single muscle fibers.

Indexed as

TorqueAgedBiopsyCase-Control StudiesFemaleHumansIsometric ContractionKnee JointMaleMuscle Fibers, SkeletalMyosin Heavy ChainsOsteoarthritis, KneeMyosin Heavy ChainsSingle muscle fiberSkinned fiberVelocity

Identifiers

PMID26343257
PMCPMC4654635

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.