Evidence map›Paper›PMID 26343037›Full record

ArticleRadiation and environmental biophysics2015

Dose and dose-rate effects of ionizing radiation: a discussion in the light of radiological protection.

Werner Rühm, Gayle E Woloschak, Roy E Shore, Tamara V Azizova, Bernd Grosche, Ohtsura Niwa, Suminori Akiba, Tetsuya Ono, Keiji Suzuki, Toshiyasu Iwasaki and 6 more

Abstract readConference Proceedings
PubMed Publisher
In one paragraph

Article in Radiation and environmental biophysics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Biological effects of high-LET irradiation on the circulatory system.International journal of radiation biology · 2025
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Radiation dose rate effects: what is new and what is needed?Radiation and environmental biophysics · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Werner RühmInstitute of Radiation Protection, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
Gayle E WoloschakDepartment of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Roy E ShoreRadiation Effects Research Foundation (RERF), 5-2 Hijiyama Park, Minami-ku, Hiroshima City, 732-0815, Japan.
Tamara V AzizovaSouthern Urals Biophysics Institute (SUBI), Ozyorskoe Shosse 19, Ozyorsk, Chelyabinsk Region, Russian Federation, 456780.
Bernd GroscheFederal Office for Radiation Protection, Ingolstaedter Landstr. 1, 85764, Oberschleissheim, Germany.
Ohtsura NiwaFukushima Medical University, Hikarigaoka 1, Fukushima, 960-1295, Japan.
Suminori AkibaDepartment of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima City, Japan.
Tetsuya OnoInstitute for Environmental Sciences, 1-7 Ienomae, Rokkasho, Aomori-ken, 039-3212, Japan.
Keiji SuzukiDepartment of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
Toshiyasu IwasakiRadiation Safety Research Center, Nuclear Technology Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI), 2-11-1 Iwado-kita, Tokyo, 201-8511, Japan.
Nobuhiko BanFaculty of Nursing, Tokyo Healthcare University, 2-5-1 Higashigaoka, Meguro, Tokyo, 152-8558, Japan.
Michiaki KaiDepartment of Environmental Health Science, Oita University of Nursing and Health Sciences, 2944-9 Megusuno, Oita, 840-1201, Japan.
Christopher H ClementInternational Commission on Radiological Protection (ICRP), PO Box 1046, Station B, 280 Slater Street, Ottawa, ON, K1P 5S9, Canada.
Simon BoufflerCentre for Radiation, Chemical and Environmental Hazards, Public Health England (PHE), Chilton, Didcot, OX11 ORQ, UK.
Hideki TomaJAPAN NUS Co., Ltd. (JANUS), 7-5-25 Nishi-Shinjuku, Shinjuku-Ku, Tokyo, 160-0023, Japan.
Nobuyuki HamadaInternational Commission on Radiological Protection (ICRP), PO Box 1046, Station B, 280 Slater Street, Ottawa, ON, K1P 5S9, Canada. hamada@icrp.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The biological effects on humans of low-dose and low-dose-rate exposures to ionizing radiation have always been of major interest. The most recent concept as suggested by the International Commission on Radiological Protection (ICRP) is to extrapolate existing epidemiological data at high doses and dose rates down to low doses and low dose rates relevant to radiological protection, using the so-called dose and dose-rate effectiveness factor (DDREF). The present paper summarizes what was presented and discussed by experts from ICRP and Japan at a dedicated workshop on this topic held in May 2015 in Kyoto, Japan. This paper describes the historical development of the DDREF concept in light of emerging scientific evidence on dose and dose-rate effects, summarizes the conclusions recently drawn by a number of international organizations (e.g., BEIR VII, ICRP, SSK, UNSCEAR, and WHO), mentions current scientific efforts to obtain more data on low-dose and low-dose-rate effects at molecular, cellular, animal and human levels, and discusses future options that could be useful to improve and optimize the DDREF concept for the purpose of radiological protection.

Indexed as

Dose-Response Relationship, RadiationRadiation, IonizingAnimalsCell Physiological PhenomenaHumansModels, BiologicalRadiation DosageRadiation InjuriesRadiation ProtectionRisk AssessmentDDREFDREFICRPLDEFLNT modelRadiation risk

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.