ArticleJournal of biomedical informatics2015
Leveraging MEDLINE indexing for pharmacovigilance - Inherent limitations and mitigation strategies.
Article in Journal of biomedical informatics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic analysis and data mining of opioid-related adverse events submitted to the FAERS database.Experimental biology and medicine (Maywood, N.J.) · 2023Pooled it
- Impact of literature reports on drug safety signals.Wiener klinische Wochenschrift · 2021Pooled it
- RxNorm for drug name normalization: a case study of prescription opioids in the FDA adverse events reporting system.Frontiers in bioinformatics · 2023Article
- The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Complementing Observational Signals with Literature-Derived Distributed Representations for Post-Marketing Drug Surveillance.Drug safety · 2020Article
- Identifying Herbal Adverse Events From Spontaneous Reporting Systems Using Taxonomic Name Resolution Approach.Bioinformatics and biology insights · 2020Article
- Finding medication doses in the liteature.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2018Article
- Toward multimodal signal detection of adverse drug reactions.Journal of biomedical informatics · 2017Article
- Harnessing scientific literature reports for pharmacovigilance. Prototype software analytical tool development and usability testing.Applied clinical informatics · 2017Article
- Generalized enrichment analysis improves the detection of adverse drug events from the biomedical literature.BMC bioinformatics · 2016Article
- A curated and standardized adverse drug event resource to accelerate drug safety research.Scientific data · 2016Article
- Automated Summarization of Publications Associated with Adverse Drug Reactions from PubMed.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2016Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundTraditional approaches to pharmacovigilance center on the signal detection from spontaneous reports, e.g., the U.S. Food and Drug Administration (FDA) adverse event reporting system (FAERS). In order to enrich the scientific evidence and enhance the detection of emerging adverse drug events that can lead to unintended harmful outcomes, pharmacovigilance activities need to evolve to encompass novel complementary data streams, for example the biomedical literature available through MEDLINE.
objectives(1) To review how the characteristics of MEDLINE indexing influence the identification of adverse drug events (ADEs); (2) to leverage this knowledge to inform the design of a system for extracting ADEs from MEDLINE indexing; and (3) to assess the specific contribution of some characteristics of MEDLINE indexing to the performance of this system.
methodsWe analyze the characteristics of MEDLINE indexing. We integrate three specific characteristics into the design of a system for extracting ADEs from MEDLINE indexing. We experimentally assess the specific contribution of these characteristics over a baseline system based on co-occurrence between drug descriptors qualified by adverse effects and disease descriptors qualified by chemically induced.
resultsOur system extracted 405,300 ADEs from 366,120 MEDLINE articles. The baseline system accounts for 297,093 ADEs (73%). 85,318 ADEs (21%) can be extracted only after integrating specific pre-coordinated MeSH descriptors and additional qualifiers. 22,889 ADEs (6%) can be extracted only after considering indirect links between the drug of interest and the descriptor that bears the ADE context.
conclusionsIn this paper, we demonstrate significant improvement over a baseline approach to identifying ADEs from MEDLINE indexing, which mitigates some of the inherent limitations of MEDLINE indexing for pharmacovigilance. ADEs extracted from MEDLINE indexing are complementary to, not a replacement for, other sources.
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