ArticleJournal of chromatography. A2015
A direct and rapid method to determine cyanide in urine by capillary electrophoresis.
Article in Journal of chromatography. A, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 34 citations in OpenAlex.
- Naked-Eye Chromogenic Test Strip for Cyanide Sensing Based on Novel Phenothiazine Push-Pull Derivatives.Biosensors · 2022Article
- Development of a cost-effective laser diode-induced fluorescence detection instrument for cyanide detection.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2022Article
- Ion Chromatography with Pulsed Amperometric Detection for Determining Cyanide in Urine and Meconium Samples.Molecules (Basel, Switzerland) · 2021Article
- Distance-Based Paper Device Combined with Headspace Extraction for Determination of Cyanide.Sensors (Basel, Switzerland) · 2019Article
- Alternate injections coupled with flow-gated capillary electrophoresis for rapid and accurate quantitative analysis of urine samples.Analytica chimica acta · 2017Article
- Cyanides in the environment-analysis-problems and challenges.Environmental science and pollution research international · 2017Review
- Rapid labeling of amino acid neurotransmitters with a fluorescent thiol in the presence of o-phthalaldehyde.Electrophoresis · 2017Article
- Development of an Analytical Protocol for Determination of Cyanide in Human Biological Samples Based on Application of Ion Chromatography with Pulsed Amperometric Detection.Journal of analytical methods in chemistry · 2017Article
- Determination of cyanide in urine and saliva samples by ion chromatography with pulsed amperometric detection.Monatshefte fur chemie · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cyanides are poisonous chemicals that widely exist in nature and industrial processes as well as accidental fires. Rapid and accurate determination of cyanide exposure would facilitate forensic investigation, medical diagnosis, and chronic cyanide monitoring. Here, a rapid and direct method was developed for the determination of cyanide ions in urinary samples. This technique was based on an integrated capillary electrophoresis system coupled with laser-induced fluorescence (LIF) detection. Cyanide ions were derivatized with naphthalene-2,3-dicarboxaldehyde (NDA) and a primary amine (glycine) for LIF detection. Three separate reagents, NDA, glycine, and cyanide sample, were mixed online, which secured uniform conditions between samples for cyanide derivatization and reduced the risk of precipitation formation of mixtures. Conditions were optimized; the derivatization was completed in 2-4min, and the separation was observed in 25s. The limit of detection (LOD) was 4.0nM at 3-fold signal-to-noise ratio for standard cyanide in buffer. The cyanide levels in urine samples from smokers and non-smokers were determined by using the method of standard addition, which demonstrated significant difference of cyanide levels in urinary samples from the two groups of people. The developed method was rapid and accurate, and is anticipated to be applicable to cyanide detection in waste water with appropriate modification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.