ArticleDrug and alcohol dependence2015
Laboratory-induced stress and craving among individuals with prescription opioid dependence.
Article in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Opioid craving does not incubate over time in inpatient or outpatient treatment studies: Is the preclinical incubation of craving model lost in translation?Neuroscience and biobehavioral reviews · 2024Pooled it
- The Impact of Co-occurring Post-traumatic Stress Disorder and Substance Use Disorders on Craving: A Systematic Review of the Literature.Frontiers in psychiatry · 2021Pooled it
- DHEA as a Biomarker of Stress: A Systematic Review and Meta-Analysis.Frontiers in psychiatry · 2021Pooled it
- Transcutaneous Cervical Vagus Nerve Stimulation Modulates Prefrontal Cortex Activity During Opioid Withdrawal in Individuals With Opioid Use Disorder.Neuromodulation : journal of the International Neuromodulation Society · 2025Trial
- Cue-induced cocaine craving enhances psychosocial stress and vice versa in chronic cocaine users.Translational psychiatry · 2022Trial
- Effects of arousal modulation via resonance breathing on craving and affect in women with substance use disorder.Addictive behaviors · 2022Trial
- Laboratory-induced stress and craving predict opioid use during follow-up among individuals with prescription opioid use disorder.Drug and alcohol dependence · 2021Trial
- Sleep moderates the relationship between stress and craving in individuals with opioid use disorder.Experimental and clinical psychopharmacology · 2021Trial
- Endocannabinoids and related lipids linked to social exclusion in individuals with chronic non-medical prescription opioid use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Noninvasive Vagal Nerve Stimulation for Opioid Use Disorder.Annals of depression and anxiety · 2023Article
- Impact of cannabidiol on reward- and stress-related neurocognitive processes among individuals with opioid use disorder: A pilot, double-blind, placebo-controlled, randomized cross-over trial.Frontiers in psychiatry · 2023Article
- Blunted cortisol and normal sympathetic nervous system responses to an acute psychosocial stressor in internet addiction.Heliyon · 2022Article
- Heightened autonomic reactivity to negative affective stimuli among active duty soldiers with PTSD and opioid-treated chronic pain.Psychiatry research · 2022Article
- Motives for prescription opioid use: The role of alexithymia and distress tolerance.The American journal on addictions · 2022Article
- Responses to social evaluative stress in regular cannabis smokers.Journal of psychopharmacology (Oxford, England) · 2021Article
- Behavioral predictors of individual differences in opioid addiction vulnerability as measured using i.v. self-administration in rats.Drug and alcohol dependence · 2021Review
- Ambulatory Assessment Methods to Examine Momentary State-Based Predictors of Opioid Use Behaviors.Current addiction reports · 2021Review
- Emotionally valenced stimuli impact response inhibition in those with substance use disorder and co-occurring anxiety and depression symptoms.Journal of affective disorders · 2020Article
- Negative Affect-Related Factors Have the Strongest Association with Prescription Opioid Misuse in a Cross-Sectional Cohort of Patients with Chronic Pain.Pain medicine (Malden, Mass.) · 2020Article
- The Opioid-Addicted Tetrapartite Synapse.Biological psychiatry · 2020Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundStress and conditioned drug cues have been implicated in the initiation, maintenance and relapse to substances of abuse. Although stress and drug cues are often encountered together, little research exists on whether stress potentiates the response to drug cues.
methodParticipants (N=75) were 39 community recruited individuals with current prescription opioid (PO) dependence and 36 healthy controls. Participants stayed overnight in the hospital for one night and then completed laboratory testing the following morning. During laboratory testing, participants were randomly assigned to a stress task (Trier Social Stress Task; TSST) or a no-stress condition. Following the stress manipulation, all participants completed a PO cue paradigm. Immediately before and after the stress and cue tasks, the following were assessed: subjective (stress, craving, anger, sadness, happiness), physiological (heart rate, blood pressure, galvanic skin response), and neuroendocrine responses (cortisol and dehydroepiandrosterone).
resultsInternal validity of the stress task was demonstrated, as evidenced by significantly higher subjective stress, as well as cortisol, heart rate and blood pressure in the TSST compared to the no-stress group. Individuals with PO dependence evidenced significantly greater reactivity to the stress task than controls. Craving increased significantly in response to the drug cue task among PO participants. No stress×cue interaction was observed.
conclusionsIn this study, heightened stress reactivity was observed among individuals with PO dependence. Exposure to acute stress, however, did not potentiate craving in response to conditioned drug cues.
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