Evidence map›Paper›PMID 26342528›Full record

ArticleNeuroImage2016

Profiling neuronal ion channelopathies with non-invasive brain imaging and dynamic causal models: Case studies of single gene mutations.

Jessica R Gilbert, Mkael Symmonds, Michael G Hanna, Raymond J Dolan, Karl J Friston, Rosalyn J Moran

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 36 citations in OpenAlex.

  1. GABA-ergic Dynamics in Human Frontotemporal Networks Confirmed by Pharmaco-Magnetoencephalography.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
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  10. Pathophysiological and cognitive mechanisms of fatigue in multiple sclerosis.Journal of neurology, neurosurgery, and psychiatry · 2019
    Review
  11. Working Memory Load Modulates Neuronal Coupling.Cerebral cortex (New York, N.Y. : 1991) · 2019
    Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Jessica R GilbertVirginia Tech Carilion Research Institute, Roanoke, VA 24016, USA. Electronic address: jessg@vtc.vt.edu.
Mkael SymmondsNuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford University, Oxford OX3 9DU, UK.
Michael G HannaInstitute of Neurology, University College London, 9 Queen Square, London WC1N 3BG, UK.
Raymond J DolanMax Planck UCL Centre for Computational Psychiatry and Ageing Research, Russell Square House, 10-12 Russell Square, London WC1B 5EH, UK.
Karl J FristonWellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK.
Rosalyn J MoranVirginia Tech Carilion Research Institute, Roanoke, VA 24016, USA; Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Carilion Clinic · USUniversity College London · GBJohn Radcliffe Hospital · GBNational Hospital for Neurology and Neurosurgery · GB

Funding

Medical Research Council MR/K000608/1Medical Research Council MR/K000608/1MR/K000608/1Wellcome Trust 088130Wellcome Trust 091593Wellcome Trust 091593/Z/10/ZWellcome Trust 098362Wellcome Trust 098362/Z/12/ZWellcome Trust 104033
6 · The paper itself

Abstract

Clinical assessments of brain function rely upon visual inspection of electroencephalographic waveform abnormalities in tandem with functional magnetic resonance imaging. However, no current technology proffers in vivo assessments of activity at synapses, receptors and ion-channels, the basis of neuronal communication. Using dynamic causal modeling we compared electrophysiological responses from two patients with distinct monogenic ion channelopathies and a large cohort of healthy controls to demonstrate the feasibility of assaying synaptic-level channel communication non-invasively. Synaptic channel abnormality was identified in both patients (100% sensitivity) with assay specificity above 89%, furnishing estimates of neurotransmitter and voltage-gated ion throughput of sodium, calcium, chloride and potassium. This performance indicates a potential novel application as an adjunct for clinical assessments in neurological and psychiatric settings. More broadly, these findings indicate that biophysical models of synaptic channels can be estimated non-invasively, having important implications for advancing human neuroimaging to the level of non-invasive ion channel assays.

Indexed as

MutationAcoustic StimulationAdultAgedAged, 80 and overAuditory CortexAuditory PerceptionBrainCalcium ChannelsCalcium Channels, N-TypeChannelopathiesComputer SimulationEvoked Potentials, AuditoryFemaleHumansMagnetoencephalographyCACNA1A protein, humanCalcium ChannelsCalcium Channels, N-TypeKCNJ2 protein, humanPotassium Channels, Inwardly RectifyingBiophysical modelsChannelopathiesDynamic causal modelingIon channel signalingMagnetoencephalography

Identifiers

PMID26342528
PMCPMC4655917
OpenAlexW1655301110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.