Evidence map›Paper›PMID 26342481›Full record

Trial reportObesity surgery2016

Randomized, Prospective Comparison of Ursodeoxycholic Acid for the Prevention of Gallstones after Sleeve Gastrectomy.

Lindsay B Adams, Craig Chang, Janet Pope, Yeonsoo Kim, Pei Liu, Amy Yates

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Obesity surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 5 pooled it
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 81 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lindsay B AdamsCollege of Applied and Natural Sciences, Louisiana Tech University, Ruston, LA, 71272, USA.
Craig Chang, 6502 Nursery Drive Suite 300, Victoria, TX, 77901, USA. craiggchangmd@gmail.com.
Janet PopeCollege of Applied and Natural Sciences, Louisiana Tech University, Ruston, LA, 71272, USA.
Yeonsoo KimCollege of Applied and Natural Sciences, Louisiana Tech University, Ruston, LA, 71272, USA.
Pei LiuCollege of Applied and Natural Sciences, Louisiana Tech University, Ruston, LA, 71272, USA.
Amy YatesCollege of Applied and Natural Sciences, Louisiana Tech University, Ruston, LA, 71272, USA.
Louisiana Tech University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral studies have examined the role of ursodeoxycholic acid (UDCA) for the prevention of cholelithiasis (gallstones) following rapid weight loss from restrictive diets, vertical band gastroplasty, and Roux-en-Y gastric bypass. However, to date, there have been no prospective, controlled studies examining the role of UDCA for the prevention of gallstones following sleeve gastrectomy (SG). This study was conducted to identify the effectiveness of UDCA for prevention of gallstones after SG.

methodsFollowing SG, eligible patients were randomized to a control group who did not receive UDCA treatment or to a group who were prescribed 300 mg UDCA twice daily for 6 months. Gallbladder ultrasounds were performed preoperatively and at 6 and 12 months postoperatively. Patients with positive findings preoperatively were excluded from the study. Compliance with UDCA was assessed.

resultsBetween December 2011 and April 2013, 37 patients were randomized to the UDCA treatment arm and 38 patients were randomized to no treatment. At baseline, the two groups were similar. At 6 months, the UDCA group had a statistically significant lower incidence of gallstones (p = 0.032). Analysis revealed no significant difference in gallstones between the two groups at 1 year (p = 0.553 and p = 0.962, respectively). The overall gallstone formation rate was 29.8%.

conclusionsThe incidence of gallstones is higher than previously estimated in SG patients. UDCA significantly lowers the gallstone formation rate at 6 months postoperatively.

Indexed as

AdultFemaleGallstonesGastrectomyHumansMaleMiddle AgedObesity, MorbidPatient CompliancePostoperative PeriodProspective StudiesTreatment OutcomeUrsodeoxycholic AcidUrsodeoxycholic AcidCholelithiasisGallstonesSleeve gastrectomyUrsodeoxycholic acidUrsodiol

Identifiers

PMID26342481
OpenAlexW1799739187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.