ArticleToxicological sciences : an official journal of the Society of Toxicology2015
In Vitro Toxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Environmental influences on macrophage epigenetics and trained immunity: a review.Molecular biology reports · 2026Review
- Climate Change and New Challenges for Rural Communities: Particulate Matter Matters.Sustainability · 2023Article
- The Roles of Histone Post-Translational Modifications in the Formation and Function of a Mitotic Chromosome.International journal of molecular sciences · 2022Review
- Emerging Insights into the Impact of Air Pollution on Immune-Mediated Asthma Pathogenesis.Current allergy and asthma reports · 2022Review
- Effects of ingested nanocellulose and nanochitosan materials on carbohydrate digestion and absorption in an in vitro small intestinal epithelium model.Environmental science. Nano · 2021Article
- Cardiovascular health impacts of wildfire smoke exposure.Particle and fibre toxicology · 2021Review
- Effects of ingested nanocellulose on intestinal microbiota and homeostasis in Wistar Han rats.NanoImpact · 2020Article
- Sex-Specific Effects of Dietary Methionine Restriction on the Intestinal Microbiome.Nutrients · 2020Article
- Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (Life sciences in space research · 2019Article
- Toxicological effects of ingested nanocellulose in in vitro intestinal epithelium and in vivo rat models.Environmental science. Nano · 2019Article
- Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System.Journal of visualized experiments : JoVE · 2016Article
- Redox/methylation mediated abnormal DNA methylation as regulators of ambient fine particulate matter-induced neurodevelopment related impairment in human neuronal cells.Scientific reports · 2016Article
- DNA methylation in the pathophysiology of hyperphenylalaninemia in the PAH(enu2) mouse model of phenylketonuria.Molecular genetics and metabolism · 2016Article
- Particulate matter, the newborn methylome, and cardio-respiratory health outcomes in childhood.Environmental epigenetics · 2016Article
- In vivo epigenetic effects induced by engineered nanomaterials: A case study of copper oxide and laser printer-emitted engineered nanoparticles.Nanotoxicology · 2016Article
- Air pollution, epigenetics, and asthma.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2016Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Exposure to ambient particulate matter (PM) has been associated with adverse health effects, including pulmonary and cardiovascular disease. Studies indicate that ambient PM originated from different sources may cause distinct biological effects. In this study, we sought to investigate the potential of various types of PM to cause epigenetic alterations in the in vitro system. RAW264.7 murine macrophages were exposed for 24 and 72 h to 5- and 50-μg/ml doses of the water soluble extract of 6 types of PM: soil dust, road dust, agricultural dust, traffic exhausts, biomass burning, and pollen, collected in January-April of 2014 in the area of Little Rock, Arkansas. Cytotoxicity, oxidative potential, epigenetic endpoints, and chromosomal aberrations were addressed. Exposure to 6 types of PM resulted in induction of cytotoxicity and oxidative stress in a type-, time-, and dose-dependent manner. Epigenetic alterations were characterized by type-, time-, and dose-dependent decreases of DNA methylation/demethylation machinery, increased DNA methyltransferases enzymatic activity and protein levels, and transcriptional activation and subsequent silencing of transposable elements LINE-1, SINE B1/B2. The most pronounced changes were observed after exposure to soil dust that were also characterized by hypomethylation and reactivation of satellite DNA and structural chromosomal aberrations in the exposed cells. The results of our study indicate that the water-soluble fractions of the various types of PM have differential potential to target the cellular epigenome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.