ArticleWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Inhibition of Pseudomonas aeruginosa biofilm formation on wound dressings.
Article in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Antibiotic Nanoparticles-Loaded Wound Dressings AgainstInternational journal of nanomedicine · 2024Pooled it
- Medical Fabrics with Non-Antibiotic, Supramolecular Antimicrobial Coatings: A Preventive Approach to Combat Biofilm Formation and Bacterial Dissemination.Advanced healthcare materials · 2026Article
- Diagnostic challenges and treatment approaches forFrontiers in microbiology · 2026Review
- A Clinical Assessment of the Safety and Efficacy of VELVERTInfection and drug resistance · 2026Article
- Association of Tryptophan/Kynurenine Metabolites with Healing in Chronic Venous Leg Ulcers.Advances in wound care · 2024Article
- Effect of L-arginine on cystic fibrosisAntimicrobial agents and chemotherapy · 2024Article
- Antibiotics againstPharmaceutics · 2024Article
- Article
- Enhancement of Inhibition of theInternational journal of molecular sciences · 2023Article
- Modulation of oxidative and nitrosative stress attenuates microvascular hyperpermeability in ovine model of Pseudomonas aeruginosa sepsis.Scientific reports · 2021Article
- Honey can inhibit and eliminate biofilms produced by Pseudomonas aeruginosa.Scientific reports · 2019Article
- Article
- Repair Process Impairment byFrontiers in cellular and infection microbiology · 2019Review
- Antibiofilm agents: A new perspective for antimicrobial strategy.Journal of microbiology (Seoul, Korea) · 2017Review
- Anti-biofilm effects of anthranilate on a broad range of bacteria.Scientific reports · 2017Article
- Silver Nanocoatings for Reducing the Exogenous Microbial Colonization of Wound Dressings.Materials (Basel, Switzerland) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Chronic nonhealing skin wounds often contain bacterial biofilms that prevent normal wound healing and closure and present challenges to the use of conventional wound dressings. We investigated inhibition of Pseudomonas aeruginosa biofilm formation, a common pathogen of chronic skin wounds, on a commercially available biological wound dressing. Building on prior reports, we examined whether the amino acid tryptophan would inhibit P. aeruginosa biofilm formation on the three-dimensional surface of the biological dressing. Bacterial biomass and biofilm polysaccharides were quantified using crystal violet staining or an enzyme linked lectin, respectively. Bacterial cells and biofilm matrix adherent to the wound dressing were visualized through scanning electron microscopy. D-/L-tryptophan inhibited P. aeruginosa biofilm formation on the wound dressing in a dose dependent manner and was not directly cytotoxic to immortalized human keratinocytes although there was some reduction in cellular metabolism or enzymatic activity. More importantly, D-/L-tryptophan did not impair wound healing in a splinted skin wound murine model. Furthermore, wound closure was improved when D-/L-tryptophan treated wound dressing with P. aeruginosa biofilms were compared with untreated dressings. These findings indicate that tryptophan may prove useful for integration into wound dressings to inhibit biofilm formation and promote wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.