Evidence map›Paper›PMID 26342045›Full record

ArticleClinical journal of the American Society of Nephrology : CJASN2015

Nephrolithiasis as a Risk Factor for CKD: The Atherosclerosis Risk in Communities Study.

Andrew E Kummer, Morgan Grams, Pamela Lutsey, Yuan Chen, Kunihiro Matsushita, Anna Köttgen, Aaron R Folsom, Josef Coresh

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical journal of the American Society of Nephrology : CJASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Review
  5. Article
  6. Risk Factors of Asymptomatic Kidney Stone Passage in Adults with Recurrent Kidney Stones.Clinical journal of the American Society of Nephrology : CJASN · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Epidemiology and economics of nephrolithiasis.Investigative and clinical urology · 2017
    Review
  18. Article
  19. Article
  20. DASH (Dietary Approaches to Stop Hypertension) Diet and Risk of Subsequent Kidney Disease.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Andrew E KummerDivisions of Renal Diseases and Hypertension and kumm0012@umn.edu.
Morgan GramsDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland; and.
Pamela LutseyEpidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota;
Yuan ChenDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland; and.
Kunihiro MatsushitaDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland; and.
Anna KöttgenDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland; and Freiburg University Medical Center, Freiburg, Germany.
Aaron R FolsomEpidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota;
Josef CoreshDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland; and.
Johns Hopkins University · USUniversity of Minnesota · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
NCATS NIH HHS UL1 TR001079NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CPHS HHS HHSN268201100005CPHS HHS HHSN268201100006CPHS HHS HHSN268201100007CPHS HHS HHSN268201100008CPHS HHS HHSN268201100009CPHS HHS HHSN268201100010CPHS HHS HHSN268201100011CPHS HHS HHSN268201100012C
6 · The paper itself

Abstract

BACKGROUND AND

objectivesPrevious studies demonstrated a higher risk of CKD in persons with a history of kidney stones, but these studies examined mostly white populations and did not evaluate important potential interactions such as race and plasma uric acid. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In 10,678 Atherosclerosis Risk in Communities (ARIC) study participants free of CKD at baseline (ARIC visit 4 in 1996-1998), we assessed the association between a history of nephrolithiasis (a time-varying variable, defined by a combination of self-report and diagnostic codes) and incident CKD (defined by diagnostic codes from linkage to hospitalizations and US Centers for Medicare and Medicaid Services' records).

resultsAt baseline, 856 participants had a history of nephrolithiasis; 322 developed nephrolithiasis during follow-up. Over a mean follow-up of 12 years, there were 1037 incident CKD events. Nephrolithiasis history was associated with a 29% (hazard ratio [HR], 1.29; 95% confidence interval [95% CI], 1.07 to 1.54) higher risk of CKD in demographic-adjusted analyses, but the association was no longer statistically significant after multivariable adjustment (HR, 1.09; 95% CI, 0.90 to 1.32). The multivariable-adjusted association was stronger among participants with plasma uric acid levels ≤6 mg/dl (HR, 1.34; 95% CI, 1.05 to 1.72) compared with those with levels >6 mg/dl (HR, 0.94; 95% CI, 0.70 to 1.28; P(interaction) = 0.05). There was no interaction of stone disease and race with incident CKD.

conclusionsIn this community-based cohort, nephrolithiasis was not an independent risk factor for incident CKD overall. However, risk of CKD was unexpectedly elevated in participants with stone disease and lower plasma uric acid levels.

Indexed as

AtherosclerosisFemaleHumansMaleMiddle AgedNephrolithiasisProspective StudiesRenal Insufficiency, ChronicRisk FactorsUric AcidUric Acidchronic kidney diseasefollow-up studieshospitalizationkidney calculinephrolithiasisrenal insufficiency, chronicrisk factorsuric acid

Identifiers

PMID26342045
PMCPMC4633798
OpenAlexW1840587514

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.