ArticlePsychiatry research2015
Brain structure and function correlates of cognitive subtypes in schizophrenia.
Article in Psychiatry research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Brain Morphological Characteristics of Cognitive Subgroups of Schizophrenia-Spectrum Disorders and Bipolar Disorder: A Systematic Review with Narrative Synthesis.Neuropsychology review · 2023Pooled it
- Cerebellar gray matter volume changes in patients with schizophrenia: A voxel-based meta-analysis.Frontiers in psychiatry · 2022Pooled it
- Systematic Review of Functional MRI Applications for Psychiatric Disease Subtyping.Frontiers in psychiatry · 2021Pooled it
- A systematic review and narrative synthesis of data-driven studies in schizophrenia symptoms and cognitive deficits.Translational psychiatry · 2020Pooled it
- Trial
- Polygenic burden associated to oligodendrocyte precursor cells and radial glia influences the hippocampal volume changes induced by aerobic exercise in schizophrenia patients.Translational psychiatry · 2019Trial
- Polygenic risk has an impact on the structural plasticity of hippocampal subfields during aerobic exercise combined with cognitive remediation in multi-episode schizophrenia.Translational psychiatry · 2017Trial
- The many-to-many problem of endophenotypes in psychiatry - a biological perspective.Molecular psychiatry · 2026Review
- Article
- Individualized cortical gradient and network topology reveal symptom-linked disruptions and neurobiological subtypes in schizophrenia.medRxiv : the preprint server for health sciences · 2026Article
- Integrated clinical and postmortem profiling in schizophrenia reveals a cognitive subtype linked to cerebrovascular disease.Translational psychiatry · 2026Article
- Driving Performance in Schizophrenia: The Role of Neurocognitive Correlates-A Systematic Review.Brain sciences · 2025Review
- Transdiagnostic types of formal thought disorder and their association with gray matter brain structure: a model-based cluster analytic approach.Molecular psychiatry · 2025Article
- Revealing multiple biological subtypes of schizophrenia through a data-driven approach.Journal of translational medicine · 2025Article
- Subgroups of cognitive impairments in schizophrenia characterized by executive function and their morphological features: a latent profile analysis study.BMC medicine · 2025Article
- A Scalable Approach to Independent Vector Analysis by Shared Subspace Separation for Multi-Subject fMRI Analysis.Sensors (Basel, Switzerland) · 2023Article
- Cortical morphological heterogeneity of schizophrenia and its relationship with glutamatergic receptor variations.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- Increased Functional Connectivity Involving the Parahippocampal Gyrus in Patients with Schizophrenia during Theory of Mind Processing: A Psychophysiological Interaction Study.Brain sciences · 2023Article
- Evidence for embracing normative modeling.eLife · 2023Article
- Cognitive subgroups and the relationships with symptoms, psychosocial functioning and quality of life in first-episode non-affective psychosis: a cluster-analysis approach.Frontiers in psychiatry · 2023Article
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Authors and funding
10 authors.
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Abstract
Stable neuropsychological deficits may provide a reliable basis for identifying etiological subtypes of schizophrenia. The aim of this study was to identify clusters of individuals with schizophrenia based on dimensions of neuropsychological performance, and to characterize their neural correlates. We acquired neuropsychological data as well as structural and functional magnetic resonance imaging from 129 patients with schizophrenia and 165 healthy controls. We derived eight cognitive dimensions and subsequently applied a cluster analysis to identify possible schizophrenia subtypes. Analyses suggested the following four cognitive clusters of schizophrenia: (1) Diminished Verbal Fluency, (2) Diminished Verbal Memory and Poor Motor Control, (3) Diminished Face Memory and Slowed Processing, and (4) Diminished Intellectual Function. The clusters were characterized by a specific pattern of structural brain changes in areas such as Wernicke's area, lingual gyrus and occipital face area, and hippocampus as well as differences in working memory-elicited neural activity in several fronto-parietal brain regions. Separable measures of cognitive function appear to provide a method for deriving cognitive subtypes meaningfully related to brain structure and function. Because the present study identified brain-based neural correlates of the cognitive clusters, the proposed groups of individuals with schizophrenia have some external validity.
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