Evidence map›Paper›PMID 26341939›Full record

ReviewNeuroscience and biobehavioral reviews2015

Implications of cortical balanced excitation and inhibition, functional heterogeneity, and sparseness of neuronal activity in fMRI.

Jiansong Xu

Abstract readReview
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Task-specific network interactions across key cognitive domains.Cerebral cortex (New York, N.Y. : 1991) · 2022
    Article
  4. Article
  5. Article
  6. Extinction learning alters the neural representation of conditioned fear.Cognitive, affective & behavioral neuroscience · 2020
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Jiansong XuDepartment of Psychiatry, Yale University, School of Medicine, 1 Church St., Room 729, New Haven, CT 06519, USA. Electronic address: Jiansong.xu@yale.edu.

Funding

FMRI & DTI Study on Neural Predictor of Treatment Outcome of Cocaine DependenceK01DA027750 · NIDA · YALE UNIVERSITY · PI XU, JIANSONG · 2010 to 2014
$881k
NIDA NIH HHS K01 DA027750
6 · The paper itself

Abstract

Blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) studies often report inconsistent findings, probably due to brain properties such as balanced excitation and inhibition and functional heterogeneity. These properties indicate that different neurons in the same voxels may show variable activities including concurrent activation and deactivation, that the relationships between BOLD signal and neural activity (i.e., neurovascular coupling) are complex, and that increased BOLD signal may reflect reduced deactivation, increased activation, or both. The traditional general-linear-model-based-analysis (GLM-BA) is a univariate approach, cannot separate different components of BOLD signal mixtures from the same voxels, and may contribute to inconsistent findings of fMRI. Spatial independent component analysis (sICA) is a multivariate approach, can separate the BOLD signal mixture from each voxel into different source signals and measure each separately, and thus may reconcile previous conflicting findings generated by GLM-BA. We propose that methods capable of separating mixed signals such as sICA should be regularly used for more accurately and completely extracting information embedded in fMRI datasets.

Indexed as

Data Interpretation, StatisticalCerebral CortexFunctional NeuroimagingHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingGeneral linear modelHemodynamic response functionIndependent component analysisMagnetic resonance imagingNeuroimagingNeurovascular coupling

Identifiers

PMID26341939
PMCPMC4623927

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.