ArticleSocial cognitive and affective neuroscience2016
Theory of mind network activity is altered in subjects with familial liability for schizophrenia.
Article in Social cognitive and affective neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Interactive behavior in mothers with and without borderline personality disorder: non-hostile behavior is associated with stronger neural activation of the theory of mind network in response to sad faces of the own child.Frontiers in psychiatry · 2025Article
- No Sex-based Differences in Self-reported Empathy between Patients with Schizophrenia and Control Subjects.Actas espanolas de psiquiatria · 2024Article
- Neural processing associated with cognitive empathy in pedophilia and child sexual offending.Social cognitive and affective neuroscience · 2022Article
- Neural correlates of RDoC-specific cognitive processes in a high-functional autistic patient: a statistically validated case report.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- The representation of mental state information in schizophrenia and first-degree relatives: a multivariate pattern analysis of fMRI data.Social cognitive and affective neuroscience · 2021Article
- Neural Correlates of Mentalizing in Individuals With Clinical High Risk for Schizophrenia: ALE Meta-Analysis.Frontiers in psychiatry · 2021Review
- Hyperfunctioning of the right posterior superior temporal sulcus in response to neutral facial expressions presents an endophenotype of schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Dopamine-dependent social information processing in non-human primates.Psychopharmacology · 2018Article
- Prefrontal Cortex and Social Cognition in Mouse and Man.Frontiers in psychology · 2015Review
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Authors and funding
17 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As evidenced by a multitude of studies, abnormalities in Theory of Mind (ToM) and its neural processing might constitute an intermediate phenotype of schizophrenia. If so, neural alterations during ToM should be observable in unaffected relatives of patients as well, since they share a considerable amount of genetic risk. While behaviorally, impaired ToM function is confirmed meta-analytically in relatives, evidence on aberrant function of the neural ToM network is sparse and inconclusive. The present study therefore aimed to further explore the neural correlates of ToM in relatives of schizophrenia. About 297 controls and 63 unaffected first-degree relatives of patients with schizophrenia performed a ToM task during functional magnetic resonance imaging. Consistent with the literature relatives exhibited decreased activity of the medial prefrontal cortex. Additionally, increased recruitment of the right middle temporal gyrus and posterior cingulate cortex was found, which was related to subclinical paranoid symptoms in relatives. These results further support decreased medial prefrontal activation during ToM as an intermediate phenotype of genetic risk for schizophrenia. Enhanced recruitment of posterior ToM areas in relatives might indicate inefficiency mechanisms in the presence of genetic risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.