ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life2016
Thiosulfate-Hydrogen Peroxide Redox Oscillator as pH Driver for Ribozyme Activity in the RNA World.
Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Hydrogen peroxide on Mars and icy moons: Implications for the search for extraterrestrial signatures of prebiotic chemistry.Fundamental research · 2026Review
- Tectonically-driven oxidant production in the hot biosphere.Nature communications · 2022Article
- The life story of hydrogen peroxide II: a periodic pH and thermochemical drive for the RNA world.Journal of the Royal Society, Interface · 2015Article
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2 authors at 2 institutions in 2 countries.
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Abstract
The RNA world of more than 3.7 billion years ago may have drawn on thermal and pH oscillations set up by the oxidation of thiosulfate by hydrogen peroxide (the THP oscillator) as a power source to drive replication. Since this primordial RNA also must have developed enzyme functionalities, in this work we examine the responses of two simple ribozymes to a THP periodic drive, using experimental rate and thermochemical data in a dynamical model for the coupled, self-consistent evolution of all reactants and intermediates. The resulting time traces show that ribozyme performance can be enhanced under pH cycling, and that thermal cycling may have been necessary to achieve large performance gains. We discuss three important ways in which the dynamic hydrogen peroxide medium may have acted as an agent for development of the RNA world towards a cellular world: proton gradients, resolution of the ribozyme versus replication paradox, and vesicle formation.
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