Evidence map›Paper›PMID 26341496›Full record

ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016

Overexpression of long non-coding RNA HOTAIR leads to chemoresistance by activating the Wnt/β-catenin pathway in human ovarian cancer.

Jing Li, Siqin Yang, Ning Su, Yuan Wang, Jinjin Yu, Haifeng Qiu, Xiaoying He

RetractedErratum issuedAbstract readRetracted Publication
PubMed Publisher
In one paragraph

Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. MiRNAs: main players of cancer drug resistance target ABC transporters.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
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  6. Re-Sensitizing Cancer Stem Cells to Conventional Chemotherapy Agents.International journal of molecular sciences · 2023
    Review
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  8. Review
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  13. MicroRNAs as the critical regulators of cisplatin resistance in gastric tumor cells.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021
    Review
  14. Article
  15. Article
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  17. Article
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  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Jing LiDepartment of Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Siqin YangDepartment of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated International Peace Maternity and Child Health Hospital, No. 910, Hengshan Road, Xujiahui District, Shanghai, 200030, China.
Ning SuDepartment of Gynecologic Oncology, the Affiliated Cancer Hospital of Zhengzhou University and Henan Provincal Cancer Hospital, Zhengzhou, Henan Province, 450008, China.
Yuan WangDepartment of Obstetrics and Gynecology, the Affiliated Hospital of Jiangnan University and the 4th People's Hospital of Wuxi, Wuxi, Jiangsu Province, 214062, China.
Jinjin YuDepartment of Obstetrics and Gynecology, the Affiliated Hospital of Jiangnan University and the 4th People's Hospital of Wuxi, Wuxi, Jiangsu Province, 214062, China.
Haifeng QiuDepartment of Obstetrics and Gynecology, the First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Erqi District, Zhengzhou, Henan Province, 450052, China. haifengqiu120@gmail.com.
Xiaoying HeDepartment of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated International Peace Maternity and Child Health Hospital, No. 910, Hengshan Road, Xujiahui District, Shanghai, 200030, China. hexiaoying06@gmail.com.
First Affiliated Hospital of Zhengzhou University · CNWuxi Fourth People's Hospital · CNHenan Cancer Hospital · CNInternational Peace Maternity & Child Health Hospital · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overexpression of HOTAIR (HOX antisense intergenic RNA) is significantly correlated with tumor progression and poor prognosis in human ovarian cancer. However, the underlying mechanisms are largely unknown. In the present study, we investigated the roles of HOTAIR in the initiation and chemoresistance of ovarian cancer. As our data show, HOTAIR overexpression promoted cell cycle progression (and thus cell proliferation) by activating the wnt/β-catenin signaling pathway. Likewise, knockdown of HOTAIR suppressed cell proliferation and arrested cell cycle at G1 phase via inhibition of wnt/β-catenin signaling. Moreover, the results of primary culture demonstrated that elevated HOTAIR expression correlated positively with chemoresistance in ovarian cancer. In vitro and in vivo, HOTAIR induced cellular resistance to cisplatin by activating the wnt/β-catenin pathway, which could be reversed by pre-treatment with the wnt/β-catenin inhibitor, XAV939. In conclusion, HOTAIR promotes the initiation and chemoresistance of ovarian cancer by activating wnt/β-catenin signaling, suggesting that HOTAIR might be a potent therapeutic target for ovarian cancer treatment.

Indexed as

AgedAnimalsBlotting, WesternCell ProliferationDrug Resistance, NeoplasmFemaleGene Expression Regulation, NeoplasticHeterograftsHumansImmunohistochemistryMiceMice, NudeMiddle AgedOvarian NeoplasmsReverse Transcriptase Polymerase Chain ReactionRNA, Long NoncodingHOTAIR long untranslated RNA, humanRNA, Long NoncodingCell cycleChemoresistanceHOTAIRLong non-coding RNAOvarian cancerProliferation

Identifiers

PMID26341496
OpenAlexW4230788549

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.