SynthesisExperimental biology and medicine (Maywood, N.J.)2016
Beyond emotions: A meta-analysis of neural response within face processing system in social anxiety.
Synthesis in Experimental biology and medicine (Maywood, N.J.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 6 syntheses or guidelines pooled it, 154 citations in OpenAlex.
- Prefrontal-limbic circuit modulation in anxiety disorders: Differential neural effects of psychotherapy versus pharmacotherapy revealed by ALE meta-analysis.Dialogues in clinical neuroscience · 2026Pooled it
- Regional Brain Activity Alterations in Social Anxiety Disorder Revealed by Seed-Based d Mapping With Permutation of Subject Images.Brain and behavior · 2026Pooled it
- Neural correlates of implicit emotion regulation in mood and anxiety disorders: an fMRI meta-analytic review.Scientific reports · 2025Pooled it
- Abnormal neural activation during negative emotion processing in anxiety disorders: a coordinate-based meta-analysis.CNS spectrums · 2024Pooled it
- Parsing variability in borderline personality disorder: a meta-analysis of neuroimaging studies.Translational psychiatry · 2021Pooled it
- Addressing reverse inference in psychiatric neuroimaging: Meta-analyses of task-related brain activation in common mental disorders.Human brain mapping · 2017Pooled it
- Identifying a structural brain network for social anxiety: connectome-based predictive modeling and network analyses in a transdiagnostic sample.Translational psychiatry · 2026Article
- Why are you looking at me like that? Intolerance of uncertainty and emotional face processing in social anxiety disorder.NeuroImage. Clinical · 2026Article
- Sensitivity and Bias in Face-Emotion Labeling: Replication and Extension to Youth With Irritability and Anxiety.JAACAP open · 2026Article
- Spatiotemporal dynamics of multispectral oscillatory activity underlying the processing of negative and positive emotional images.NeuroImage · 2025Article
- Oscillatory brain dynamics underlying affective face processing.Social cognitive and affective neuroscience · 2025Article
- Adolescent social anxiety is associated with diminished discrimination of anticipated threat and safety in the bed nucleus of the stria terminalis.Journal of psychopathology and clinical science · 2025Article
- Resting-state functional magnetic resonance imaging and support vector machines for the diagnosis of major depressive disorder in adolescents.World journal of psychiatry · 2024Review
- Abnormal large-scale brain functional network dynamics in social anxiety disorder.CNS neuroscience & therapeutics · 2024Article
- Research hotspots and trends of neuroimaging in social anxiety: a CiteSpace bibliometric analysis based on Web of Science and Scopus database.Frontiers in behavioral neuroscience · 2024Review
- Pre-COVID brain network topology prospectively predicts social anxiety alterations during the COVID-19 pandemic.Neurobiology of stress · 2023Article
- Large-scale brain functional network abnormalities in social anxiety disorder.Psychological medicine · 2023Article
- Understanding anxiety symptoms as aberrant defensive responding along the threat imminence continuum.Neuroscience and biobehavioral reviews · 2023Review
- Baby Brains at Work: How Task-Based Functional Magnetic Resonance Imaging Can Illuminate the Early Emergence of Psychiatric Risk.Biological psychiatry · 2023Review
- Deep learning applied to EEG source-data reveals both ventral and dorsal visual stream involvement in holistic processing of social stimuli.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 4 countries.
Funding
Abstract
Patients with social anxiety disorder (SAD) experience anxiety and avoidance in face-to-face interactions. We performed a meta-analysis of functional magnetic resonance imaging (fMRI) studies in SAD to provide a comprehensive understanding of the neural underpinnings of face perception in this disorder. To this purpose, we adopted an innovative approach, asking authors for unpublished data. This is a common procedure for behavioral meta-analyses, which, however has never been used in neuroimaging studies. We searched Pubmed with the key words "Social Anxiety AND faces" and "Social Phobia AND faces." Then, we selected those fMRI studies for which we were able to obtain data for the comparison between SAD and healthy controls (HC) in a face perception task, either from the published papers or from the authors themselves. In this way, we obtained 23 studies (totaling 449 SAD and 424 HC individuals). We identified significant clusters in which faces evoked a higher response in SAD in bilateral amygdala, globus pallidus, superior temporal sulcus, visual cortex, and prefrontal cortex. We also found a higher activity for HC in the lingual gyrus and in the posterior cingulate. Our findings show that altered neural response to face in SAD is not limited to emotional structures but involves a complex network. These results may have implications for the understanding of SAD pathophysiology, as they suggest that a dysfunctional face perception process may bias patient person-to-person interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.