Evidence map›Paper›PMID 26341461›Full record

ArticleOphthalmology2015

Ocular Complications in Children with Diabetes Mellitus.

Megan M Geloneck, Brian J Forbes, James Shaffer, Gui-shuang Ying, Gil Binenbaum

Open access · greenAbstract read
In one paragraph

Article in Ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Observational
  4. Article
  5. Building capacity: paediatric vision screening in elementary schools.International journal of circumpolar health · 2025
    Article
  6. Recommended practices for vision screening in pre-school-age children: A 2025 update.Optometry and vision science : official publication of the American Academy of Optometry · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Current Approach to the Pathogenesis of Diabetic Cataracts.International journal of molecular sciences · 2023
    Review
  14. Causal Relationships Between Glycemic Traits and Myopia.Investigative ophthalmology & visual science · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Megan M GeloneckThe Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Brian J ForbesThe Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
James ShafferScheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Gui-shuang YingScheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Gil BinenbaumThe Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: binenbaum@email.chop.edu.
Children's Hospital of Philadelphia · USPenn Presbyterian Medical Center · US

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI CLAIRE H MITCHELL · 1985 to 2026
$19.5M
Short Term Research Training for Medical StudentsT35DK060441 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI WOLF, BRYAN A · 2002 to 2011
$543k
QUANTIMET 900 IMAGE ANALYSING SYSTEMS10RR002499 · NCRR · YESHIVA UNIVERSITY · PI BROWN, LUCY L · 1985 to 1985
–
NCRR NIH HHS UL1RR02499NEI NIH HHS L30 EY018451NEI NIH HHS L30 EY018451-03NEI NIH HHS P30 EY001583NEI NIH HHS P30 EY01583-26NIDDK NIH HHS 5T35DK060441-10NIDDK NIH HHS T35 DK060441
6 · The paper itself

Abstract

purposeThe effectiveness of annual eye examinations in diabetic children is unclear. We sought to determine the prevalence and onset of ocular pathology in children with diabetes mellitus (DM), identify risk factors for ocular disease, and recommend a screening regimen for asymptomatic children.

designRetrospective, consecutive cohort study.

participantsChildren aged less than 18 years with type 1 or 2 DM examined over a 4-year period.

methodsAll children underwent a complete eye examination, including dilated fundoscopy and cycloplegic refraction. A literature review was performed, identifying the youngest reported age and shortest reported duration of DM before the diagnosis of diabetic retinopathy (DR).

main outcome measuresPrevalence of DR, cataract, high refractive error, and strabismus.

resultsA total of 370 children (mean age, 11.2 years; range, 1-17.5 years) had 693 examinations, with a mean DM duration of 5.2 years (range, 0.1-16.2 years) and a mean hemoglobin A1c (HbA1c) of 8.6 (range, 5-≥14). No children had DR. A total of 12 children had cataract; 5 required extraction but were identified by decreased vision, not diabetic screening. A total of 19 children had strabismus; only 1 was microvascular paralytic strabismus. A total of 41 children had high refractive error. There were no associations between these conditions and duration or control of DM. In the literature, the youngest age at diagnosis of severe DR was 15 years, and the shortest duration of disease was 5 years.

conclusionsDiabetic retinopathy is rare in children regardless of duration and control of DM. On the basis of our study and literature review, screening examinations for type 1 diabetes could begin at age 15 years or at 5 years after the diagnosis of DM, whichever occurs later, unless the child is judged by the endocrinologist as being at unusually high risk. Other ocular complications are identifiable through existing amblyopia screening methods.

Indexed as

AdolescentBlood GlucoseChildChild, PreschoolDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic RetinopathyFemaleGlycated HemoglobinHumansInfantMaleRefraction, OcularRefractive ErrorsRetrospective StudiesRisk FactorsBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, human

Identifiers

PMID26341461
PMCPMC4769865
OpenAlexW1149094239

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.