Evidence map›Paper›PMID 26341354›Full record

ArticleClinical neuroradiology2017

Langerhans Cell Histiocytosis of the Temporal Bone with Otic Capsule Involvement.

J M Blumberg, A Malhotra, X Wu, R K Virk, J F Kveton, E M Michaelides

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In one paragraph

Article in Clinical neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

J M BlumbergDepartment of Surgery, Section of Otolaryngology, Yale School of Medicine, 333 Cedar St, 06520-8042, New Haven, CT, USA.
A MalhotraDepartment of Diagnostic Radiology, Yale School of Medicine, Tompkins East 2, 333 Cedar St, 06520-8042, Box 208042, New Haven, CT, USA. ajay.malhotra@yale.edu.
X WuDepartment of Diagnostic Radiology, Yale School of Medicine, 333 Cedar St, 06520-8042, New Haven, CT, USA.
R K VirkDepartment of Pathology, Yale School of Medicine, 333 Cedar St, 06520-8042, New Haven, CT, USA.
J F KvetonEar, Nose & Throt Medical and Surgical Group, Section of Otolaryngology, Yale School of Medicine, New Haven, CT, USA.
E M MichaelidesDepartment of Surgery, Section of Otolaryngology, Yale School of Medicine, 333 Cedar St, 06520-8042, New Haven, CT, USA.
Yale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study is conducted to demonstrate that destructive lesions of the otic capsule by Langerhans cell histiocytosis (LCH) causing both radiographic and audiologic findings can be completely reversed with adequate treatment. Retrospective case review and analysis of clinical and imaging data were obtained as part of the diagnosis and treatment of patients with LCH of the temporal bone.

methodsWith Institutional Review Board (IRB) approval, cases of LCH involving the temporal bone were searched for within the institutional databases. Criteria for inclusion was histologic diagnosis of LCH and pretreatment computed tomography (CT) demonstrating temporal bone and/or otic capsule involvement and posttreatment follow-up CT/magnetic resonance imaging (MRI) scans obtained at least 6 months after starting treatment.

resultsWe report eight cases of LCH of the temporal bone with three demonstrating otic capsule involvement radiographically and/or clinically. Review of posttreatment imaging revealed all three patients had complete restoration of the bony labyrinthine architecture and near or complete restoration of their hearing.

conclusionsThough LCH of the temporal bone is a common site within the spectrum of the disease, involvement of the otic capsule remains rare. Here, we report the largest series of otic capsule involvement by LCH and investigate whether both architecture and hearing are recovered with appropriate treatment. Lastly, restoration of the bony architecture of the labyrinth suggests the mechanism of LCH is demineralization and not ablative.

Indexed as

Child, PreschoolDiagnosis, DifferentialEar, InnerFemaleHistiocytosis, Langerhans-CellHumansMagnetic Resonance ImagingMaleRetrospective StudiesTemporal BoneTomography, X-Ray ComputedTreatment OutcomeHistiocytosisOtic capsuleTemporal bone

Identifiers

PMID26341354
OpenAlexW1544780084

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.