ArticleMolecular biology and evolution2015
Bayesian Inference Reveals Host-Specific Contributions to the Epidemic Expansion of Influenza A H5N1.
Article in Molecular biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- One Health genomic surveillance reveals structured urban rabies transmission and major surveillance gaps.bioRxiv : the preprint server for biology · 2026Article
- HIV Transmission Dynamics in Greater Mexico City are Shaped by Dense Spatial Mixing.Research square · 2026Article
- Predicting high pathogenicity avian influenza H5N1 susceptibility in wild birds.Scientific reports · 2026Article
- Dynamics and ecology of a multistage expansion of Oropouche virus in Brazil.Nature ecology & evolution · 2026Article
- HIV Transmission Dynamics in Greater Mexico City are Shaped by Dense Spatial Mixing.medRxiv : the preprint server for health sciences · 2026Article
- Disentangling the drivers and host-mediated global spread of H7 influenza A virus.Nature communications · 2026Article
- Evolutionary history of Jamestown Canyon virus reveals complex multi-vector ecology.Current biology : CB · 2026Article
- Mapping global avian influenza risk patterns through waterbird activity entropy.Nature communications · 2026Article
- Evolution of H5N1 Cross-Species Transmission: Adaptive Mutations Driving Avian-to-Human Infection.Advanced genetics (Hoboken, N.J.) · 2026Article
- SERAPHIM 2.0: an extended toolbox for studying phylogenetically informed movements.Bioinformatics (Oxford, England) · 2026Article
- Evolutionary history of Jamestown Canyon virus disentangles complex multi-vector ecology.bioRxiv : the preprint server for biology · 2026Article
- Continuous phylogeography reveals shifting environmental drivers of highly pathogenic avian influenza H5 spread in Italy, 2016-23.Virus evolution · 2026Article
- Phylodynamic analyses reveal persistence and extensive intermixing of Usutu virus in the Netherlands.Virus evolution · 2026Article
- Article
- Comparative performance of viral landscape phylogeography approaches.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The recency and geographical origins of the bat viruses ancestral to SARS-CoV and SARS-CoV-2.Cell · 2025Article
- Genesis and Spread of Novel Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Genotype EA-2023-DG Reassortant, Western Europe.Emerging infectious diseases · 2025Article
- Tracing more than two decades of Japanese encephalitis virus circulation in mainland China.Journal of virology · 2025Article
- Quantifying Time-Dependent Predictors for the International Spatial Spread of Highly Pathogenic Avian Influenza H5NX: Focus on Trade and Surveillance Efforts.Transboundary and emerging diseases · 2025Article
- Lost in the woods: shifting habitats can lead phylogeography astray.Virus evolution · 2025Article
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5 authors.
Funding
Abstract
Since its first isolation in 1996 in Guangdong, China, the highly pathogenic avian influenza virus (HPAIV) H5N1 has circulated in avian hosts for almost two decades and spread to more than 60 countries worldwide. The role of different avian hosts and the domestic-wild bird interface has been critical in shaping the complex HPAIV H5N1 disease ecology, but remains difficult to ascertain. To shed light on the large-scale H5N1 transmission patterns and disentangle the contributions of different avian hosts on the tempo and mode of HPAIV H5N1 dispersal, we apply Bayesian evolutionary inference techniques to comprehensive sets of hemagglutinin and neuraminidase gene sequences sampled between 1996 and 2011 throughout Asia and Russia. Our analyses demonstrate that the large-scale H5N1 transmission dynamics are structured according to different avian flyways, and that the incursion of the Central Asian flyway specifically was driven by Anatidae hosts coinciding with rapid rate of spread and an epidemic wavefront acceleration. This also resulted in long-distance dispersal that is likely to be explained by wild bird migration. We identify a significant degree of asymmetry in the large-scale transmission dynamics between Anatidae and Phasianidae, with the latter largely representing poultry as an evolutionary sink. A joint analysis of host dynamics and continuous spatial diffusion demonstrates that the rate of viral dispersal and host diffusivity is significantly higher for Anatidae compared with Phasianidae. These findings complement risk modeling studies and satellite tracking of wild birds in demonstrating a continental-scale structuring into areas of H5N1 persistence that are connected through migratory waterfowl.
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