ArticlePediatric nephrology (Berlin, Germany)2016
Plasma levels of oxidative stress in children with steroid-sensitive nephrotic syndrome and their predictive value for relapse frequency.
Article in Pediatric nephrology (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Oxidative Stress in Children and Adolescents: Insights Into Human Biology.American journal of human biology : the official journal of the Human Biology Council · 2025Review
- Pediatric nephrotic syndrome: The interplay of oxidative stress and inflammation.Journal of medical biochemistry · 2024Article
- Genetic risk variants for childhood nephrotic syndrome and corticosteroid response.Frontiers in pediatrics · 2023Article
- Review
- Predictors of frequent relapsing and steroid-dependent nephrotic syndrome in children.Turk pediatri arsivi · 2018Article
- NOX-mediated impairment of PDGF-induced DNA synthesis in peripheral blood lymphocytes of children with idiopathic nephrotic syndrome.Pediatric research · 2017Article
- Increased ischemia-modified albumin levels in children with steroid-sensitive nephrotic syndrome.Pakistan journal of medical sciencesArticle
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Authors and funding
6 authors.
Funding
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Abstract
backgroundOxidative stress has been reported to play an important role in children with primary nephrotic syndrome (PNS). However, the results of previous studies are controversial.
methodsForty children with steroid-sensitive nephrotic syndrome (SSNS) and 20 age- and sex-matched healthy controls were enrolled. Patients were followed-up for 12-18 months and divided into three subgroups: frequent relapse (n = 10), non-frequent relapse (n = 12), and non-relapse (n = 18). The plasma levels of advanced oxidation protein products (AOPP), malondialdehyde (MDA), and superoxide dismutase (SOD) were tested in controls and patient group at first presentation and after 4 weeks of steroid treatment.
resultsPatients had higher AOPP and MDA levels but lower SOD compared with controls. AOPP levels were significantly higher in the frequent relapse subgroup compared with the non-frequent relapse and non-relapse subgroups, respectively. No significant differences were found in the plasma levels of MDA and SOD among the three subgroups. AOPP >87.55 μmol/l before steroid treatment and AOPP >78.5 μmol/l after 4-week steroid treatment were positively correlated with the relapse frequency in patients with SSNS.
conclusionsChildren with SSNS have oxidative stress. The plasma levels of AOPP before and after 4-week steroid treatment may predict whether patients with SSNS will relapse frequently.
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