ArticleMolecular imaging and biology2016
Establishing On-Site Reference Values for (123)I-FP-CIT SPECT (DaTSCAN®) Using a Cohort of Individuals with Non-Degenerative Conditions.
Article in Molecular imaging and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Evaluating dopamine transporter imaging as an enrichment biomarker in a phase 2 Parkinson's disease trial.BMC neurology · 2021Trial
- The role of presynaptic dopaminergic imaging in acquired neurological conditions affecting basal ganglia: a systematic review.Frontiers in neurology · 2025Review
- Sex differences in dementia with Lewy bodies: an imaging study of neurotransmission pathways.European journal of nuclear medicine and molecular imaging · 2023Article
- Semi-quantitative analysis of visually normalEJNMMI research · 2023Article
- In vivo human molecular neuroimaging of dopaminergic vulnerability along the Alzheimer's disease phases.Alzheimer's research & therapy · 2021Article
- Improved Performance of a Multipinhole SPECT for DAT Imaging by Increasing Number of Pinholes at the Expense of Increased Multiplexing.IEEE transactions on radiation and plasma medical sciences · 2021Article
- Impact of age and sex correction on the diagnostic performance of dopamine transporter SPECT.European journal of nuclear medicine and molecular imaging · 2021Article
- Premotor and fronto-striatal mechanisms associated with presence hallucinations in dementia with Lewy bodies.NeuroImage. Clinical · 2021Article
- Feeling of presence in dementia with Lewy bodies is related to reduced left frontoparietal metabolism.Brain imaging and behavior · 2020Article
- Single-siteEuropean journal of hybrid imaging · 2020Article
- Classification of degenerative parkinsonism subtypes by support-vector-machine analysis and striatalJournal of neurology · 2019Article
- Dopaminergic imaging separates normal pressure hydrocephalus from its mimics.Journal of neurology · 2018Article
- Consolidation of a Learned Skill Correlates with Dopamine SPECT Uptake in Early Parkinson's Disease.Journal of clinical neurology (Seoul, Korea) · 2018Article
- Response to the letter to the editor of Nicolas Nicastro et al.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Is nigrostriatal dopaminergic deficit necessary for Holmes tremor to develop? The DaTSCAN and IBZM SPECT study.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- Source-Based Morphometry Multivariate Approach to Analyze [Molecular imaging and biology · 2017Article
- The added value of combined visual and semi-quantitative assessment forNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
- Discriminating among degenerative parkinsonisms using advanced (123)I-ioflupane SPECT analyses.NeuroImage. Clinical · 2016Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo overcome the issue of reference values for DaTSCAN® requiring healthy controls, we propose an original approach using scans from individuals with non-degenerative conditions performed at one single center following the same acquisition protocol. PROCEDURES: From a cohort of 970 consecutive patients, we identified 182 patients with a clinical diagnosis of non-degenerative parkinsonism or tremor and a visually normal DATSCAN®. Caudate nucleus (C), putamen (P), and striatum (S) uptake values, C/P ratios, and asymmetry indexes (AI) were calculated using semi-quantitative methods. Outcomes were assessed according to age and gender, and reference limits were established using the percentile approach.
resultsA significant negative linear effect of age was found upon striatal nuclei uptake of 0.21-0.22 per decade (6.8%/decade for striatum), whereas a potential gender influence proved unclear. Inferior reference limits were established at the 5th percentile. C/P ratios and AIs were not influenced by age or gender, and superior reference limits were set at the 95th percentile.
conclusionsWe here propose a convenient approach to calculate site-specific reference limits for DaTSCAN® outcomes not requiring scanning healthy controls. The method appears to yield robust values that range within nearly identical limits as those obtained in healthy subjects.
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