Evidence map›Paper›PMID 26341144›Full record

ArticleNeurobiology of learning and memory2015

Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k.

Rikki Hullinger, Kenneth O'Riordan, Corinna Burger

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of learning and memory, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rikki HullingerNeuroscience Training Program, University of Wisconsin-Madison, USA.
Kenneth O'RiordanDepartment of Pharmacology & Therapeutics, Biotechnology (Watts) Building, Trinity College, Dublin 2, Ireland(1).
Corinna BurgerDepartment of Neurology, University of Wisconsin-Madison, Medical Sciences Center, 1300 University Ave, Room 73 Bardeen, Madison, WI 53706, USA; Neuroscience Training Program, University of Wisconsin-Madison, USA. Electronic address: burger@neurology.wisc.edu.
University of Wisconsin–Madison · US

Funding

NEUROSCIENCE TRAINING PROGRAMT32GM007507 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HALLORAN, MARY C · 1985 to 2017
$9.3M
Mechanisms of age related cognitive impairmentR01AG048172 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI BURGER, CORINNA · 2014 to 2018
$1.5M
NIA NIH HHS R01 AG048172NIGMS NIH HHS T32 GM007507NIGMS NIH HHS T32GM007507
6 · The paper itself

Abstract

Previous studies from our lab have demonstrated that mild cognitive impairments identified early in life are predictive of cognitive deficits that develop with age, suggesting that enhancements in cognition at an early age can provide a buffer against age-related cognitive decline. Environmental enrichment has been shown to improve learning and memory in the rodent, but the impact of enrichment on synaptic plasticity and the molecular mechanisms behind enrichment are not completely understood. To address these unresolved issues, we have housed 2-month old rats in environmentally enriched (EE), socially enriched (SE), or standard housing (SC) and conducted tests of learning and memory formation at various time intervals. Here we demonstrate that animals that have been exposed to one month of social or environmental enrichment demonstrate enhanced learning and memory relative to standard housed controls. However, we have found that after 4months EE animals perform better than both SE and SC groups and demonstrate an enhanced hippocampal LTP. Our results demonstrate that this LTP is dependent on mGluR5 signaling, activation of ERK and mTOR signaling cascades, and sustained phosphorylation of p70s6 kinase, thus providing a potential target mechanism for future studies of cognitive enhancement in the rodent.

Indexed as

EnvironmentAnimalsExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsHousing, AnimalLearningLong-Term PotentiationMemoryPhosphorylationPyridinesRatsReceptor, Metabotropic Glutamate 5Ribosomal Protein S6 Kinases, 70-kDaSignal Transduction6-methyl-2-(phenylethynyl)pyridineExcitatory Amino Acid AntagonistsGrm5 protein, ratPyridinesReceptor, Metabotropic Glutamate 5Ribosomal Protein S6 Kinases, 70-kDaEnvironmental enrichmentMetabotropic glutamate receptorMorris water mazeObject recognitionp70s6 kinaseYoung rats

Identifiers

PMID26341144
PMCPMC4938427
OpenAlexW1586256036

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.