SynthesisAmerican journal of Alzheimer's disease and other dementias2016
A Meta-Analysis of C-Reactive Protein in Patients With Alzheimer's Disease.
Synthesis in American journal of Alzheimer's disease and other dementias, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Peripheral immune function and Alzheimer's disease: a living systematic review and critical appraisal.Molecular psychiatry · 2024Pooled it
- IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer's disease: Systematic Review and Meta-Analysis.Scientific reports · 2018Pooled it
- Mindfulness improves inflammatory biomarker levels in older adults with mild cognitive impairment: a randomized controlled trial.Translational psychiatry · 2020Trial
- Association between neutrophil to lymphocyte ratio and Alzheimer's disease in large biobank cohorts.Journal of Alzheimer's disease : JAD · 2025Article
- Serum Biomarkers of Vascular Dysfunction, Neuropsychiatric Symptoms, and Clinical Severity of Alzheimer's Disease: A Cross-sectional Study.Current Alzheimer research · 2025Observational
- An Investigation into the Relationship of Circulating Gut Microbiome Molecules and Inflammatory Markers with the Risk of Incident Dementia in Later Life.Molecular neurobiology · 2024Article
- Systemic inflammation, lifestyle behaviours and dementia: A 10-year follow-up investigation.Brain, behavior, & immunity - health · 2024Article
- White matter hyperintensity volume modifies the association between CSF vascular inflammatory biomarkers and regional FDG-PET along the Alzheimer's disease continuum.Neurobiology of aging · 2023Article
- Association of mTOR Pathway and Conformational Alterations in C-Reactive Protein in Neurodegenerative Diseases and Infections.Cellular and molecular neurobiology · 2023Review
- The Role of Steroidomics in the Diagnosis of Alzheimer's Disease and Type 2 Diabetes Mellitus.International journal of molecular sciences · 2023Article
- Recent Development in the Understanding of Molecular and Cellular Mechanisms Underlying the Etiopathogenesis of Alzheimer's Disease.International journal of molecular sciences · 2023Review
- Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- Adiposity and the risk of dementia: mediating effects from inflammation and lipid levels.European journal of epidemiology · 2022Article
- C-reactive protein levels and risk of dementia-Observational and genetic studies of 111,242 individuals from the general population.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Women with lower systemic inflammation demonstrate steeper cognitive decline with age: Results from a large prospective, longitudinal sample.Brain, behavior, & immunity - health · 2022Article
- Elevated C-Reactive Protein in Alzheimer's Disease Without Depression in Older Adults: Findings From the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Increased YKL-40 but Not C-Reactive Protein Levels in Patients with Alzheimer's Disease.Biomedicines · 2021Article
- Serum Amyloid Beta42 Is Not Eliminated by the Cirrhotic Liver: A Pilot Study.Journal of clinical medicine · 2021Article
- Regulated upon activation, normal T cell expressed and secreted (RANTES) levels in the peripheral blood of patients with Alzheimer's disease.Neural regeneration research · 2021Article
- Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study.Neurobiology of aging · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammation may be associated with Alzheimer's disease (AD). This meta-analysis aimed to compare the level of C-reactive protein (CRP) in patients having AD to healthy controls. A total of 10 cross-sectional studies (n = 2093) were identified from PubMed and EMBASE after systematic searching and evaluation. The combined standardized mean difference (SMD) of CRP level between the disease and control group was analyzed. In the meta-analysis, there was no significant difference in serum between the CRP level of patients with AD and that of healthy controls (SMD: -0.400, 95% confidence interval [CI]: -0.827 to 0.027,P= .066). However, when we stratified the studies by Mini-Mental State Examination (MMSE) scores, the level of CRP in the mild and moderate dementia subgroup (MMSE ≥ 10) was significantly lower than that in the control group (SMD: -0.582, 95% CI: -0.957 to -0.208,P= .002). Therefore, the diagnostic value of CRP for mild and moderate AD may be useful in clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.