ArticleJournal of autism and developmental disorders2016
Does the cognitive architecture of simplex and multiplex ASD families differ?
Article in Journal of autism and developmental disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Research Review: Outcomes of 24- to 36-month-old children with autism spectrum disorder vary by ascertainment strategy: a systematic review and meta-analysis.Journal of child psychology and psychiatry, and allied disciplines · 2020Pooled it
- Transgenerational Effects and Heritability of Folate Receptor Alpha Autoantibodies in Autism Spectrum Disorder.International journal of molecular sciences · 2025Article
- Review of autism spectrum disorder databases for the identification of candidate genes.Database : the journal of biological databases and curation · 2025Review
- Examination of Clinical and Assessment Type Differences Between Toddlers with ASD from Multiplex and Simplex Families.Journal of autism and developmental disorders · 2024Article
- Heterogeneity of autism symptoms in community-referred infants and toddlers at elevated or low familial likelihood of autism.Autism research : official journal of the International Society for Autism Research · 2023Article
- Evaluating causal psychological models: A study of language theories of autism using a large sample.Frontiers in psychology · 2023Article
- Complex response inhibition and cognitive flexibility in school-aged Cypriot-Greek-speaking children who stutter.Frontiers in psychology · 2022Article
- Article
- Developmental Trajectories of Infants With Multiplex Family Risk for Autism: A Baby Siblings Research Consortium Study.JAMA neurology · 2020Article
- The Performance of the First Year Inventory (FYI) Screening on a Sample of High-Risk 12-Month-Olds Diagnosed with Autism Spectrum Disorder (ASD) at 36 Months.Journal of autism and developmental disorders · 2019Article
- Theory of Mind Performance in Broad Autism Phenotype Groups: Between-Group Differences and Predictor Variables.Journal of autism and developmental disorders · 2019Article
- Differences in Cognition and Behaviour in Multiplex and Simplex Autism: Does Prior Experience Raising a Child with Autism Matter?Journal of autism and developmental disorders · 2019Article
- Brief Report: Characteristics of preschool children with ASD vary by ascertainment.Journal of autism and developmental disorders · 2017Article
- The relation between family familiarity with autism and developmental outcomes.Neurodiversity (Thousand Oaks (Ventura County, Calif.))Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Children with an autism spectrum disorder (ASD) and their unaffected siblings from 54 simplex (SPX, one individual in the family affected) and 59 multiplex (MPX, two or more individuals affected) families, and 124 controls were assessed on intelligence, social cognition and executive functions. SPX and MPX ASD probands displayed similar cognitive profiles, but within-family contrasts were highest in SPX families, suggesting SPX-MPX stratification may help parse etiological heterogeneity of ASD. Unaffected siblings (regardless SPX or MPX) were mostly unimpaired, suggesting that cognitive problems may be part of the defining features of ASD, rather than being an endophenotypic trait. Except for affective prosody, which appeared to be the most sensitive cognitive marker for detecting familial risk for ASD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.