ArticlePloS one2015
Impacts of Co-Existing Chronic Rhinosinusitis on Disease Severity and Risks of Exacerbations in Chinese Adults with Bronchiectasis.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- The association between chronic rhinosinusitis, bronchiectasis and type 2 inflammation: an EMBARC registry analysis.ERJ open research · 2026Article
- Bronchiectasis and sinonasal diseases: a narrative review.ERJ open research · 2025Review
- Addressing treatable traits in bronchiectasis through non-pharmacological therapies: a narrative review.Journal of thoracic disease · 2025Review
- Cough in non-cystic fibrosis bronchiectasis.ERJ open research · 2024Article
- Prevalence of chronic rhinosinusitis and its relating factors in patients with bronchiectasis: findings from KMBARC registry.The Korean journal of internal medicine · 2022Article
- Strong and consistent associations of precedent chronic rhinosinusitis with risk of non-cystic fibrosis bronchiectasis.The Journal of allergy and clinical immunology · 2022Article
- The clinical impact of self-reported symptoms of chronic rhinosinusitis in people with bronchiectasis.Immunity, inflammation and disease · 2022Article
- Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases.Frontiers in cell and developmental biology · 2020Review
- Prevalence and characterization of chronic rhinosinusitis in patients with non-cystic fibrosis bronchiectasis at a tertiary care center in the United States.International forum of allergy & rhinology · 2019Article
- Vitamin DChronic respiratory disease · 2018Article
- Bronchiectasis Management in China, What We Can Learn from European Respiratory Society Guidelines.Chinese medical journal · 2018Article
- Motile Ciliary Disorders in Chronic Airway Inflammatory Diseases: Critical Target for Interventions.Current allergy and asthma reports · 2018Review
- Upper airway involvement in bronchiectasis is marked by early onset and allergic features.ERJ open research · 2018Article
- Chronic rhinosinusitis is associated with higher prevalence and severity of bronchiectasis in patients with COPD.International journal of chronic obstructive pulmonary disease · 2017Article
- Risk Factors and Comorbidities in Chronic Rhinosinusitis.Current allergy and asthma reports · 2016Review
- Screening and impact of comorbidities in bronchiectasis: a forward-looking perspective.Therapeutic advances in respiratory diseaseReview
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMounting evidence supports the notion of "one airway, one disease."
objectiveTo determine whether chronic rhinosinusitis (CRS) poses adverse impacts on Chinese adults with bronchiectasis.
methodsWe enrolled 148 consecutive adults with clinically stable bronchiectasis. CRS diagnosed based on the 2012 EP3OS criteria. We systematically evaluated the bronchiectasis etiology, radiology, lung function, sputum bacteriology, airway inflammatory biomarkers, Bronchiectasis Severity Index, cough sensitivity and healthcare resource utilization. All patients were prospectively followed-up for 1 year to examine the frequency of bronchiectasis exacerbations (BEs).
resultsForty-seven patients (31.8%) were diagnosed as having CRS. Bronchiectasis etiologies did not vary statistically between CRS and no-CRS group. There was a trend towards non-statistically higher Bronchiectasis Severity Index [6.4±3.4 vs. 5.0(6.0), P = 0.19], a higher proportion of patients with BEs needing hospitalization before enrollment (48.9% vs. 29.7%, P = 0.13), poorer FVC [78.2±19.8% vs. 82.2(16.8)%, P = 0.54] and FEV1 [68.2±24.8% vs. 74.8(21.2)%, P = 0.29], a higher prevalence of Pseudomonas aeruginosa isolated (36.2% vs. 26.7%, P = 0.27) or colonized in sputum (36.2% vs. 21.8%, P = 0.12) and greater capsaicin cough sensitivity [C2: 3.9(123.0) μmol/L vs. 11.7(123.0) μmol/L, P = 0.81; C5: 62.5(996.0) μmol/L vs. 250.0(973.0) μmol/L, P = 0.32]. Patients with CRS had significantly greater risks of experiencing BEs during follow-up (P = 0.02 for negative binominal regression test).
conclusionChinese adults with bronchiectasis appear to have a lower prevalence of CRS than that in western countries. There was a trend towards greater adverse impacts on bronchiectasis in patients with CRS. Studies with greater sample sizes might help to resolve this issue. In future clinical practice, physicians should be vigilant to the screening of concomitant CRS in bronchiectasis so as to better improve patient's healthcare. Our findings may be of clinical significance in that proper treatment of upper airway symptoms due to CRS will be the prevention of infection or re-infection of the tracheobronchial tree, which should be addressed for the future management of bronchiectasis.
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