The Path from Pluripotency to Skeletal Muscle: Developmental Myogenesis Guides the Way.

Michael Hicks, April Pyle

Abstract readComment

In one paragraph

Article in Cell stem cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

Bioprocessing Considerations towards the Manufacturing of Therapeutic Skeletal and Smooth Muscle Cells.Bioengineering (Basel, Switzerland) · 2023
Review
Multilineage Differentiation for Formation of Innervated Skeletal Muscle Fibers from Healthy and Diseased Human Pluripotent Stem Cells.Cells · 2020
Article
Towards stem cell therapies for skeletal muscle repair.NPJ Regenerative medicine · 2020
Review
An In Vitro Human Segmentation Clock Model Derived from Embryonic Stem Cells.Cell reports · 2019
Article
Lactational programming of glucose homeostasis: a window of opportunity.Reproduction (Cambridge, England) · 2018
Review
Concise Review: Stem Cell Fate Guided By Bioactive Molecules for Tendon Regeneration.Stem cells translational medicine · 2018
Review

4 · The record

Corrections and comments

Comment on
Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy.2015

5 · Who and what money

Authors and funding

2 authors.

Michael HicksDepartment of Microbiology, Immunology and Molecular Genetics, Center for Duchenne Muscular Dystrophy, and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095, USA.

April PyleDepartment of Microbiology, Immunology and Molecular Genetics, Center for Duchenne Muscular Dystrophy, and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095, USA. Electronic address: apyle@mednet.ucla.edu.

Funding

Reprogramming and Directed Differentiation of Skeletal Muscle Cells from hPSCs.R01AR064327 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI April D Pyle · 2013 to 2026

$6.4M

NIAMS NIH HHS R01 AR064327

6 · The paper itself

Abstract

Following cues from mouse embryogenesis, Chal et al. (2015) identified key regulators of skeletal myogenesis from mouse and human pluripotent stem cells. Emerging myogenic progenitors were specified to form multinucleated fibers that enabled development of quiescent, satellite cell-like progenitors and a model for Duchenne Muscular Dystrophy.

Indexed as

Cell DifferentiationDisease Models, AnimalAnimalsMuscle Fibers, SkeletalMuscular Dystrophy, DuchennePluripotent Stem Cells

Identifiers

PMID26340524

DOI10.1016/j.stem.2015.08.017

PMCPMC4940037

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.