Evidence map›Paper›PMID 26340521›Full record

ArticleCell stem cell2015

Adaption by Rewiring Epigenetic Landscapes.

Yifei Liu, Andrew Xiao

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Maternal O-GlcNAc Transferase Is Required for the Asymmetry of Epigenetic Modifications in Mouse Zygotes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yifei LiuDepartment of Genetics and Yale Stem Cell Center, Yale University, New Haven, CT 06519, USA.
Andrew XiaoDepartment of Genetics and Yale Stem Cell Center, Yale University, New Haven, CT 06519, USA. Electronic address: andrew.xiao@yale.edu.
Yale Cancer Center · US

Funding

Investigate Novel Epigenetic Silencing Mechanisms in Mouse ESCsR01GM114205 · NIGMS · YALE UNIVERSITY · PI XIAO, ZHUO ANDREW · 2015 to 2019
$2.1M
NIGMS NIH HHS R01 GM114205NIGMS NIH HHS R01GM114205-01
6 · The paper itself

Abstract

Embryonic stem cells (ESCs) generally rely on repressive histone modifications to silence retrotransposons, rather than DNA methylation as in differentiated cells. In this issue of Cell Stem Cell, He et al. (2015) show that Daxx/Atrx repress transposons in ESCs devoid of 5mC, demonstrating dynamic reorganization of epigenetic networks and crosstalk between distinct repressive mechanisms to maintain transposon silencing.

Indexed as

DNA MethylationAdaptor Proteins, Signal TransducingAnimalsCarrier ProteinsDNA HelicasesHistonesHumansIntracellular Signaling Peptides and ProteinsLysineNuclear ProteinsTandem Repeat SequencesAdaptor Proteins, Signal TransducingCarrier ProteinsDNA HelicasesHistonesIntracellular Signaling Peptides and ProteinsLysineNuclear Proteins

Identifiers

PMID26340521
PMCPMC4710369
OpenAlexW1889680941

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.