Evidence map›Paper›PMID 26340421›Full record

ArticleMolecular cell2015

ATM, MacroH2A.1, and SASP: The Checks and Balances of Cellular Senescence.

Marek Kozlowski, Andreas G Ladurner

Abstract readComment
PubMed Publisher
In one paragraph

Article in Molecular cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Epigenetic changes during aging and their reprogramming potential.Critical reviews in biochemistry and molecular biology · 2019
    Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Epigenetics and aging.Science advances · 2016
    Review
  14. Dissecting cellular senescence and SASP inInflammation and regeneration · 2016
    Review
  15. Role of lncRNAs in Cellular Aging.Frontiers in endocrinology · 2016
    Review
  16. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Marek KozlowskiDepartment of Physiological Chemistry, Biomedical Center, Ludwig-Maximilians-University of Munich, Butenandtstrasse 5, 81377 Munich, Germany; International Max Planck Research School for Molecular and Cellular Life Sciences, Am Klopferspitz 18, 82152 Martinsried, Germany.
Andreas G LadurnerDepartment of Physiological Chemistry, Biomedical Center, Ludwig-Maximilians-University of Munich, Butenandtstrasse 5, 81377 Munich, Germany; International Max Planck Research School for Molecular and Cellular Life Sciences, Am Klopferspitz 18, 82152 Martinsried, Germany; Center for Integrated Protein Science Munich (CIPSM), 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany. Electronic address: andreas.ladurner@med.lmu.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oncogene activation is usually not enough to induce cancer, but causes cells to arrest proliferation, alter chromatin structure, and increase protein secretion. In this issue of Molecular Cell, Chen et al. (2015) implicate the histone variant macroH2A.1 in the regulation of senescence.

Indexed as

Ataxia Telangiectasia Mutated ProteinsCellular SenescenceHistonesHumansAtaxia Telangiectasia Mutated ProteinsHistones

Identifiers

PMID26340421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.