ArticlePloS one2015
The Long-Term Effects of Organophosphates Poisoning as a Risk Factor of CVDs: A Nationwide Population-Based Cohort Study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 119 citations in OpenAlex.
- Persistent Organic Pollutants and Heart Rate Variability: A Population-Based Cross-Sectional Study in China.Journal of the American Heart Association · 2025Article
- Environmental Toxins and Oxidative Stress: The Link to Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2025Review
- N-acetylcysteine prevents cholinergic and non-cholinergic toxic effects induced by nerve agent poisoning in rats.Toxicology research · 2025Article
- Assessing Variability in Children's Exposure to Contaminants in Food: A Longitudinal Non-Targeted Analysis Study in Miami, Florida.Journal of xenobiotics · 2025Article
- Personal Strategies to Reduce the Cardiovascular Impacts of Environmental Exposures.Circulation research · 2024Review
- Symmetrical Bispyridinium Compounds Act as Open Channel Blockers of Cation-Selective Ion Channels.ACS pharmacology & translational science · 2024Article
- Exposure to tris (1,3-dichloro-2-propyl) phosphate affects the embryonic cardiac development ofHeliyon · 2024Article
- Which risk factor best predicts coronary artery disease using artificial neural network method?BMC medical informatics and decision making · 2024Article
- Review
- Synergistic action of organophosphates and COVID-19 on inflammation, oxidative stress, and renin-angiotensin system can amplify the risk of cardiovascular maladies.Toxicology and applied pharmacology · 2022Article
- Social and environmental risks as contributors to the clinical course of heart failure.Heart failure reviews · 2022Review
- Determinants of Hypertension amongst Rice Farmers in West Java, Indonesia.International journal of environmental research and public health · 2022Article
- Pesticide Use Knowledge, Attitude, Practices and Practices Associated Factors Among Floriculture Workers in Bahirdar City, North West, Ethiopia, 2020.Environmental health insights · 2022Article
- Bioaccumulation of Organophosphorus (OPs) and Carbamate (CBs) Residues in Cultured Pangas Catfish (Journal of toxicology · 2022Article
- Cardiotoxicity of some pesticides and their amelioration.Environmental science and pollution research international · 2021Review
- Cardiac injury in organophosphate poisoning after acute ingestion.Toxicology research · 2021Article
- Obesity, Nutrition and Heart Rate Variability.International journal of molecular sciences · 2021Review
- A Fluidics-Based Biosensor to Detect and Characterize Inhibition Patterns of Organophosphate to Acetylcholinesterase in Food Materials.Micromachines · 2021Article
- The Effect of Organophosphate Exposure on Neuronal Cell Coenzyme QNeurochemical research · 2021Article
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOrganophosphorus pesticides are widely used throughout the world. Because of their ease of availability, organophosphorus compounds are commonly used for self-poisoning in developing countries. The acute effects of exposure to organophosphorus pesticides are well known, but the chronic effects are unclear. Recent studies suggest that abnormalities of the central and peripheral nervous systems persisted for up to 5 years after acute poisoning due to a single large dose of organophosphates (OPs). However, the long-term effects on cardiovascular diseases are poorly understood. METHODOLOGY/PRINCIPAL
findingsAn OPs-exposed cohort (N = 7,561) and an age- and gender-matched control cohort (N = 30,244), both identified from the National Health Insurance Research Database, were compared. We utilized the multivariable Cox proportional model to estimate the risks of developing arrhythmia, coronary artery disease (CAD) and congestive heart failure (CHF). The patients with acute poisoning from OPs had higher incidence rates of arrhythmia (5.89 vs. 3.61 per 1,000 person-years), CAD (9.10 vs. 6.88 per 1,000 person-years), and CHF (3.89 vs. 2.98 per 1,000 person-years) compared with that of the non-OPs poisoning cohort, with a crude subhazard ratio (SHR) of 1.40, 1.13, and 1.12, respectively. Additionally, a significantly higher risk of arrhythmia was observed in the OPs poisoning cohort (adjusted SHR = 1.25) compared with the non-OPs poisoning cohort, particularly in male patients (adjusted SHR = 1.33) and those under 49 years of age (adjusted SHR = 3.16). After accounting for the competing risks of death, there was a higher risk of arrhythmia and CAD during a three year follow-up period (adjusted SHR = 1.50 for arrhythmia; adjusted SHR = 1.10 for CAD). We also found an adjusted SHR of 1.36 associated with developing CHF after 6 years of follow-up for OPs poisoning cohort.
conclusionsAcute OPs poisoning may continuously impact human health through mechanisms that are unclear. Any supportive measurements that could contribute to a reduction in the risk of heart disease may be beneficial in cases of OPs poisoning survivors.
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