ArticleThe Journal of physiology2016
Twenty-eight days of exposure to 3454 m increases mitochondrial volume density in human skeletal muscle.
Article in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers in Highly Trained Male Distance Runners.Sports medicine (Auckland, N.Z.) · 2025Trial
- Plasticity and evolved changes in mitochondrial physiology across skeletal muscles of high-altitude deer mice (Peromyscus maniculatus).The Journal of experimental biology · 2026Article
- The effects of graded hypoxia on gene expression related to oxygen sensing and metabolism.Scientific reports · 2025Article
- The Impact of a High-Altitude Expedition on the Physical Performance and Nutritional Indices of Health Status of Alpinists.Journal of functional morphology and kinesiology · 2025Article
- The impact of high altitude (hypobaric hypoxia) on insulin resistance in humans.Journal of physiology and biochemistry · 2025Review
- Physiological and Genetic Basis of High-Altitude Indigenous Animals' Adaptation to Hypoxic Environments.Animals : an open access journal from MDPI · 2024Review
- Evolved changes in phenotype across skeletal muscles in deer mice native to high altitude.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- The Oxygen Cascade from Atmosphere to Mitochondria as a Tool to Understand the (Mal)adaptation to Hypoxia.International journal of molecular sciences · 2023Review
- Training at moderate altitude improves submaximal but not maximal performance-related parameters in elite rowers.Frontiers in physiology · 2022Article
- Fifteen days of moderate normobaric hypoxia does not affect mitochondrial function, and related genes and proteins, in healthy men.European journal of applied physiology · 2021Article
- Could mitochondria help athletes to make gains?Nature · 2021Article
- Comparison of Muscle Density in Middle-Aged and Older Chinese Adults Between a High-Altitude Area (Kunming) and a Low-Altitude Area (Beijing).Frontiers in endocrinology · 2021Article
- Body Composition and Body Weight Changes at Different Altitude Levels: A Systematic Review and Meta-Analysis.Frontiers in physiology · 2019Review
- Adaptive remodeling of skeletal muscle energy metabolism in high-altitude hypoxia: Lessons from AltitudeOmics.The Journal of biological chemistry · 2018Article
- Properties of the vastus lateralis muscle in relation to age and physiological function in master cyclists aged 55-79 years.Aging cell · 2018Article
- Hemoglobin Changes After Long-Term Intermittent Work at High Altitude.Frontiers in physiology · 2018Article
- Evolved changes in the intracellular distribution and physiology of muscle mitochondria in high-altitude native deer mice.The Journal of physiology · 2017Article
- Hypoxia, fetal and neonatal physiology: 100 years on from Sir Joseph Barcroft.The Journal of physiology · 2016Article
- Mitochondrial Regulation of the Muscle Microenvironment in Critical Limb Ischemia.Frontiers in physiology · 2015Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of hypoxia on skeletal muscle mitochondria is controversial. Studies superimposing exercise training on hypoxic exposure demonstrate an increase in skeletal muscle mitochondrial volume density (Mito(VD)) over equivalent normoxic training. In contrast, reductions in both skeletal muscle mass and Mito(VD) have been reported following mountaineering expeditions. These observations may, however, be confounded by negative energy balance, which may obscure the results. Accordingly we sought to examine the effects of high altitude hypoxic exposure on mitochondrial characteristics, with emphasis on Mito(VD), while minimizing changes in energy balance. For this purpose, skeletal muscle biopsies were obtained from nine lowlanders at sea level (Pre) and following 7 and 28 days of exposure to 3454 m. Maximal ergometer power output, whole body weight and composition, leg lean mass and skeletal muscle fibre area all remained unchanged following the altitude exposure. Transmission electron microscopy determined that intermyofibrillar (IMF) Mito(VD) was augmented (P = 0.028) by 11.5 ± 9.2% from Pre (5.05 ± 0.9%) to 28 Days (5.61 ± 0.04%). In contrast, there was no change in subsarcolemmal (SS) Mito(VD). As a result, total Mito(VD) (IMF + SS) was increased (P = 0.031) from 6.20 ± 1.5% at Pre to 6.62 ± 1.4% at 28 Days (7.8 ± 9.3%). At the same time no changes in mass-specific respiratory capacities, mitochondrial protein or antioxidant content were found. This study demonstrates that skeletal muscle Mito(VD) may increase with 28 days acclimation to 3454 m.
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