ArticleAnnals of clinical and translational neurology2015
Acute seizure suppression by transcranial direct current stimulation in rats.
Article in Annals of clinical and translational neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Transcranial current stimulation in epilepsy: A systematic review of the fundamental and clinical aspects.Frontiers in neuroscience · 2022Pooled it
- Memory and Cognition-Related Neuroplasticity Enhancement by Transcranial Direct Current Stimulation in Rodents: A Systematic Review.Neural plasticity · 2020Pooled it
- Article
- The effect of combined ultrasound stimulation and gastrodin on seizures in mice.Frontiers in neuroscience · 2024Article
- Effectiveness of Anodal otDCS Following with Anodal tDCS Rather than tDCS Alone for Increasing of Relative Power of Intrinsic Matched EEG Bands in Rat Brains.Brain sciences · 2022Article
- Current and Emerging Clinical Treatment in Mitochondrial Disease.Molecular diagnosis & therapy · 2021Review
- Increase in Seizure Susceptibility After Repetitive Concussion Results from Oxidative Stress, Parvalbumin-Positive Interneuron Dysfunction and Biphasic Increases in Glutamate/GABA Ratio.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Drug-Responsive Inhomogeneous Cortical Modulation by Direct Current Stimulation.Annals of neurology · 2020Article
- Successful Treatment of Super-Refractory Status Epilepticus with High-Intensity Electroconvulsive Therapy - A Case Report and Review of the Current Literature.Journal of epilepsy research · 2019Article
- Biomarkers Obtained by Transcranial Magnetic Stimulation of the Motor Cortex in Epilepsy.Frontiers in integrative neuroscience · 2019Article
- Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats.Neural plasticity · 2019Article
- Using animal models to improve the design and application of transcranial electrical stimulation in humans.Current behavioral neuroscience reports · 2018Article
- A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility.Neurobiology of disease · 2018Article
- Preclinical to Clinical Translation of Studies of Transcranial Direct-Current Stimulation in the Treatment of Epilepsy: A Systematic Review.Frontiers in neuroscience · 2018Article
- Transcranial Magnetic and Direct Current Stimulation in Children.Current neurology and neuroscience reports · 2017Review
- Replicable in vivo physiological and behavioral phenotypes of theMolecular autism · 2017Article
- Cathodal transcranial direct-current stimulation for treatment of drug-resistant temporal lobe epilepsy: A pilot randomized controlled trial.Epilepsia open · 2016Article
- Animal models of transcranial direct current stimulation: Methods and mechanisms.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2016Review
- Direct current stimulation induces mGluR5-dependent neocortical plasticity.Annals of neurology · 2016Article
- Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCathodal transcranial direct current stimulation (tDCS) is a focal neuromodulation technique that suppresses cortical excitability by low-amplitude constant electrical current, and may have an antiepileptic effect. Yet, tDCS has not been tested in status epilepticus (SE). Furthermore, a combined tDCS and pharmacotherapy antiseizure approach is unexplored. We therefore examined in the rat pentylenetetrazol (PTZ) SE model whether cathodal tDCS (1) suppresses seizures, (2) augments lorazepam (LZP) efficacy, and (3) enhances GABAergic cortical inhibition.
methodsExperiment 1 aimed to identify an effective cathodal tDCS intensity. Rats received intraperitoneal PTZ followed by tDCS (sham, cathodal 1 mA, or cathodal 0.1 mA; for 20 min), and then a second PTZ challenge. In Experiment 2, two additional animal groups received a subtherapeutic LZP dose after PTZ, and then verum or sham tDCS. Clinical and electroencephalography (EEG) epileptic activity were compared between all groups. In Experiment 3, we measured GABA-mediated paired-pulse inhibition of the motor evoked potential by paired-pulse transcranial magnetic stimulation (ppTMS) in rats that received PTZ or saline, and either verum or sham tDCS.
resultsCathodal 1 mA tDCS (1) reduced EEG spike bursts, and suppressed clinical seizures after the second PTZ challenge, (2) in combination with LZP was more effective in seizure suppression and improved the clinical seizure outcomes compared to either tDCS or LZP alone, and (3) prevented the loss of ppTMS motor cortex inhibition that accompanied PTZ injection.
interpretationThese results suggest that cathodal 1 mA tDCS alone and in combination with LZP can suppress seizures by augmenting GABAergic cortical inhibition.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.