Evidence map›Paper›PMID 26339603›Full record

ArticleBioMed research international2015

Heterogeneity of Genetic Damage in Cervical Nuclei and Lymphocytes in Women with Different Levels of Dysplasia and Cancer-Associated Risk Factors.

Carlos Alvarez-Moya, Mónica Reynoso-Silva, Alejandro A Canales-Aguirre, José O Chavez-Chavez, Hugo Castañeda-Vázquez, Alfredo I Feria-Velasco

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In one paragraph

Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carlos Alvarez-MoyaCellular and Molecular Biology Department, Guadalajara University, Juarez 976, Colonia Centro, 44100 Guadalajara, JAL, Mexico.
Mónica Reynoso-SilvaCellular and Molecular Biology Department, Guadalajara University, Juarez 976, Colonia Centro, 44100 Guadalajara, JAL, Mexico.
Alejandro A Canales-AguirreUnit of Medical and Pharmaceutical Biotechnology, CIATEJ, Avenida Normalistas 800, Colinas de la Normal, 44270 Guadalajara, JAL, Mexico.
José O Chavez-ChavezDysplasias Unit, Institute of Cancerology Jaliscience, General Coronado 515, Colonia Centro, 44100 Guadalajara, JAL, Mexico.
Hugo Castañeda-VázquezMastitis and Molecular Diagnosis, Guadalajara University, Juarez 976, Colonia Centro, 44100 Guadalajara, JAL, Mexico.
Alfredo I Feria-VelascoCellular and Molecular Biology Department, Guadalajara University, Juarez 976, Colonia Centro, 44100 Guadalajara, JAL, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The comet assay can be used to assess genetic damage, but heterogeneity in the length of the tails is frequently observed. The aims of this study were to evaluate genetic damage and heterogeneity in the cervical nuclei and lymphocytes from patients with different levels of dysplasia and to determine the risk factors associated with the development of cervical cancer. The study included 97 females who presented with different levels of dysplasia. A comet assay was performed in peripheral blood lymphocytes and cervical epithelial cells. Significant genetic damage (P ≤ 0.05) was observed only in patients diagnosed with nuclei cervical from dysplasia III (NCDIII) and lymphocytes from dysplasia I (LDI). However, the standard deviations of the tail lengths in the cervical nuclei and lymphocytes from patients with dysplasia I were significantly different (P ≤ 0.0001) from the standard deviations of the tail lengths in the nuclei cervical and lymphocytes from patients with DII and DIII (NCDII, NCDIII and LDII, LDIII), indicating a high heterogeneity in tail length. Results suggest that genetic damage could be widely present but only manifested as increased tail length in certain cell populations. This heterogeneity could obscure the statistical significance of the genetic damage.

Indexed as

Cell NucleusDNA DamageFemaleGenetic HeterogeneityHumansLymphocytesNeoplasm ProteinsRisk FactorsUterine Cervical DysplasiaUterine Cervical Neoplasmsneoplasm-associated factorNeoplasm Proteins

Identifiers

PMID26339603
PMCPMC4538336

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.