Evidence map›Paper›PMID 26339585›Full record

SynthesisBioMed research international2015

Reproductive Factors but Not Hormonal Factors Associated with Thyroid Cancer Risk: A Systematic Review and Meta-Analysis.

Yijuan Cao, Zengyan Wang, Juan Gu, Fangfang Hu, Yujuan Qi, Qianqian Yin, Qingqing Sun, Guotao Li, Bin Quan

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 4 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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  19. Cigarette Smoking and Estrogen-Related Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Yijuan CaoReproductive Center, Central Hospital of Xuzhou, Affiliated Xuzhou Hospital of Southeast University, Xuzhou 221009, China.
Zengyan WangDepartment of Anesthesia, People's Hospital of Zhucheng, Zhucheng 262200, China.
Juan GuReproductive Center, Central Hospital of Xuzhou, Affiliated Xuzhou Hospital of Southeast University, Xuzhou 221009, China.
Fangfang HuReproductive Center, Central Hospital of Xuzhou, Affiliated Xuzhou Hospital of Southeast University, Xuzhou 221009, China.
Yujuan QiReproductive Center, Central Hospital of Xuzhou, Affiliated Xuzhou Hospital of Southeast University, Xuzhou 221009, China.
Qianqian YinReproductive Center, Central Hospital of Xuzhou, Affiliated Xuzhou Hospital of Southeast University, Xuzhou 221009, China.
Qingqing SunReproductive Center, Central Hospital of Xuzhou, Affiliated Xuzhou Hospital of Southeast University, Xuzhou 221009, China.
Guotao LiReproductive Center, The Affiliated Hospital of Weifang Medical University, Weifang 261000, China.
Bin QuanDepartment of General Surgery, Central Hospital of Xuzhou, Affiliated Xuzhou Hospital of Southeast University, Xuzhou 221009, China.
Southeast University · CNXuzhou Central Hospital · CNWeifang Medical University · CNZoucheng People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many studies have investigated the association between hormonal and reproductive factors and thyroid cancer risk but provided contradictory and inconclusive findings. This review was aimed at precisely estimating this association by pooling all available epidemiological studies. 25 independent studies were retrieved after a comprehensive literature search in databases of PubMed and Embase. Overall, common hormonal factors including oral contraceptive and hormone replacement therapy did not alter the risk of thyroid cancer. Older age at menopause was associated with weakly increased risk of thyroid cancer in overall analysis (RR = 1.24, 95% CI 1.00-1.53, P = 0.049); however, longer duration of breast feeding was related to moderately reduced risk of thyroid cancer, suggested by pooled analysis in all cohort studies (RR = 0.7, 95% CI 0.51-0.95, P = 0.021). The pooled RR in hospital-based case-control studies implicated that parous women were more susceptible to thyroid cancer than nulliparous women (RR = 2.30, 95% CI 1.31-4.04, P = 0.004). The present meta-analysis suggests that older age at menopause and parity are risk factors for thyroid cancer, while longer duration of breast feeding plays a protective role against this cancer. Nevertheless, more relevant epidemiological studies are warranted to investigate roles of hormonal and reproductive factors in thyroid carcinogenesis.

Indexed as

CarcinogenesisAge FactorsFemaleHormonesHumansMenopauseParityPregnancyPubMedReproductionRisk FactorsThyroid GlandThyroid NeoplasmsHormones

Identifiers

PMID26339585
PMCPMC4538312
OpenAlexW1627128869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.