ReviewNeural plasticity2015
Plasticity of Neuron-Glial Transmission: Equipping Glia for Long-Term Integration of Network Activity.
Review in Neural plasticity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Building transformers from neurons and astrocytes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Activation of Astrocytes in the Persistence of Post-hypoxic Respiratory Augmentation.Frontiers in physiology · 2021Article
- The Ketamine Antidepressant Story: New Insights.Molecules (Basel, Switzerland) · 2020Review
- The impact of exenatide (a GLP-1 agonist) on markers of inflammation and oxidative stress in normal human astrocytes subjected to various glycemic conditions.Experimental and therapeutic medicine · 2019Article
- Adenosine AAnatomical record (Hoboken, N.J. : 2007) · 2018Article
- Hippocampus-based contextual memory alters the morphological characteristics of astrocytes in the dentate gyrus.Molecular brain · 2016Article
- Role of Glia in Memory Deficits Following Traumatic Brain Injury: Biomarkers of Glia Dysfunction.Frontiers in integrative neuroscience · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The capacity of synaptic networks to express activity-dependent changes in strength and connectivity is essential for learning and memory processes. In recent years, glial cells (most notably astrocytes) have been recognized as active participants in the modulation of synaptic transmission and synaptic plasticity, implicating these electrically nonexcitable cells in information processing in the brain. While the concept of bidirectional communication between neurons and glia and the mechanisms by which gliotransmission can modulate neuronal function are well established, less attention has been focussed on the computational potential of neuron-glial transmission itself. In particular, whether neuron-glial transmission is itself subject to activity-dependent plasticity and what the computational properties of such plasticity might be has not been explored in detail. In this review, we summarize current examples of plasticity in neuron-glial transmission, in many brain regions and neurotransmitter pathways. We argue that induction of glial plasticity typically requires repetitive neuronal firing over long time periods (minutes-hours) rather than the short-lived, stereotyped trigger typical of canonical long-term potentiation. We speculate that this equips glia with a mechanism for monitoring average firing rates in the synaptic network, which is suited to the longer term roles proposed for astrocytes in neurophysiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.