Evidence map›Paper›PMID 26339473›Full record

ArticleF1000Research2015

Absence of kdr resistance alleles in the Union of the Comoros, East Africa.

Yoosook Lee, Natalie Olson, Youki Yamasaki, Allison Chang, Clare Marsden, Ahmed Ouledi, Gregory Lanzaro, Anthony Cornel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in F1000Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Transcontinental dispersal ofCommunications biology · 2019
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yoosook LeeVector Genetics Laboratory, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
Natalie OlsonDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, 90095, USA.
Youki YamasakiVector Genetics Laboratory, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
Allison ChangVector Genetics Laboratory, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
Clare MarsdenDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, 90095, USA.
Ahmed OulediUniversité des Comores, rue de la Corniche, Moroni, Grande Comore, Comoros.
Gregory LanzaroVector Genetics Laboratory, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
Anthony CornelVector Genetics Laboratory, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA ; Department of Entomology and Nematology, University of California, Davis, CA, 95616, USA.
University of California, Davis · USUniversity of California, Los Angeles · USUniversidade dos Açores · PT

Funding

Ecology and Genetics of An. gambiae on IslandsR21AI062929 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LANZARO, GREGORY C. · 2009 to 2010
$415k
NIAID NIH HHS R21 AI062929
6 · The paper itself

Abstract

Knockdown resistance ( kdr) and CYP9K1 genotypes were detected by a MOLDI-TOF based SNP genotyping assay (Sequenom iPLEX) in samples of Anopheles gambiae collected at 13 sites throughout the Union of the Comoros and Dar es Salaam, Tanzania during February and March 2011. All A. gambiae specimens collected in the Comoros were homozygous for the susceptible kdr alleles (+/+) while 96% of A. gambiae from Dar es Salaam were homozygous for the East African kdr resistant genotype (E/E). In contrast, all specimens from Dar es Salaam and the Comoros were homozygous for the cyp3 allele (c3/c3) at the CYP9K1 locus; the locus has been implicated in metabolic resistance against pyrethroid insecticides in West Africa. All specimens had typical A. gambiae genotypes for SNPs within the divergence Islands on all three chromosomes. Although further spatial and temporal studies are needed, the distribution of kdr genotypes between the Comoros and Tanzania further supports isolation of the Comoros populations from A. gambiae populations on mainland Africa .

Indexed as

CYP9K1Dar es SalaamDISinsecticidekncokdown resistenceresistence

Identifiers

PMID26339473
PMCPMC4544377
OpenAlexW2143243117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.