Somatic mutation in synchronous primary adenocarcinomas of the left lung: a case report.

Xiaoli Yu, Danli Sheng, Junchang Jiang, Minpu Ren, Mei Jin, Songxiao Xu

Open access · greenAbstract readCase Reports

In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 76% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiaoli YuDepartment of Pathology, Sir Run Run Shaw Hospital, Medical School, Zhejiang University Hangzhou, Zhejiang, China.

Danli ShengDepartment of Pathology, Sir Run Run Shaw Hospital, Medical School, Zhejiang University Hangzhou, Zhejiang, China.

Junchang JiangDepartment of Pathology, Sir Run Run Shaw Hospital, Medical School, Zhejiang University Hangzhou, Zhejiang, China.

Minpu RenDepartment of Pathology, Sir Run Run Shaw Hospital, Medical School, Zhejiang University Hangzhou, Zhejiang, China.

Mei JinDepartment of Pathology, Sir Run Run Shaw Hospital, Medical School, Zhejiang University Hangzhou, Zhejiang, China.

Songxiao XuDepartment of Pathology, Sir Run Run Shaw Hospital, Medical School, Zhejiang University Hangzhou, Zhejiang, China.

Sir Run Run Shaw Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple lung adenocarcinomas (AC) are uncommon. We herein report a case of multiple AC. A 62-year-old Chinese woman was admitted to our hospital because of her chest enhanced computed tomography (ECT) finding. Her ECT revealed a suspected lung cancer in the left lower lung and ill-defined weak ground-glass opacity in the left upper lobe. Upon operation, however, both were pathologically diagnosed as AC, an invasive one and an in-situ one, respectively. Only the invasive AC presented epidermal growth factor receptor (EGFR) mutation, while anaplastic lymphoma kinase (ALK) rearrangement was detected in none of them. To not miss rare invasion-related mutations, the whole exome sequencing of the in-situ and invasive AC was conducted subsequently matched the adjacent normal tissue of this patient. On sequencing the invasive tumor sample was found to have 27 exclusive somatic mutations as compared with in-situ and adjacent normal tissues. Our case exemplifies the need for deep sequencing and the discovery of new potential driver mutations.

Indexed as

MutationAdenocarcinomaAdenocarcinoma of LungBiomarkers, TumorBiopsyDNA Mutational AnalysisErbB ReceptorsFemaleGenetic Predisposition to DiseaseHigh-Throughput Nucleotide SequencingHumansLung NeoplasmsMiddle AgedMultiple Pulmonary NodulesNeoplasms, Multiple PrimaryPhenotypeBiomarkers, TumorEGFR protein, humanErbB ReceptorsMultiple lung adenocarcinomassomatic mutationwhole exome sequencing

Identifiers

PMID26339437

PMCPMC4555765

OpenAlexW2397088503

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.