ArticleInternational journal of clinical and experimental pathology2015
Biphenotypic plasma cell myeloma: two cases of plasma cell neoplasm with a coexpression of kappa and lambda light chains.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Proportion, Function, and Generation of Dual Receptor Lymphocytes.Journal of immunology research · 2026Review
- Demonstration of T-Cell Monotypia Using Anti-TCRbeta1/2 (Diagnostics (Basel, Switzerland) · 2024Article
- IgG-k/IgG-λ Para-Osseous Plasmacytoma Relapsed as Soft-Tissue Plasmacytoma with IgA-k Immunophenotype: A Case Report and Review of the Literature on Related Biochemical Aspects.Hematology reports · 2024Article
- scRNA-seq revealed the special TCR β & α V(D)J allelic inclusion rearrangement and the high proportion dual (or more) TCR-expressing cells.Cell death & disease · 2023Article
- A porcine lymphoma-derived cell line co-expressing IgM, IgG and IgA.The Journal of veterinary medical science · 2022Article
- A case of solitary plasmacytoma of bone showing co-expression of both immunoglobulin light chains.European journal of medical research · 2021Article
- Localized plantar amyloidosis: case report and review of the literature.Skeletal radiology · 2021Review
- Biclonal myeloma in renal failure.Central-European journal of immunology · 2020Article
- Localized Gastric Amyloidosis with Kappa and Lambda Light Chain Co-Expression.Clinical endoscopy · 2018Article
- Ultrasensitive automated RNA in situ hybridization for kappa and lambda light chain mRNA detects B-cell clonality in tissue biopsies with performance comparable or superior to flow cytometry.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
- Plasma cell myeloma with dual expression of kappa and lambda light chains.International journal of clinical and experimental pathology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledPlasma cell neoplasm (PCM) is a medullary and extra medullary proliferation of clonal plasma cells that occurs due to accidental translocation of proto-oncogenes into immunoglobulin (Ig) gene loci. While the majority of plasma cell neoplasms are monoclonal, up to 2% of the PCMs [1] considered being biclonal based on electrophoretic analysis, characterized by secretion of paraprotein with two distinct heavy chains or light chains are possible and present unique diagnostic challenges.
methodsTraditionally protein electrophoresis has been used to diagnose, characterize, and monitor progression of plasma cell neoplasm. To characterize neoplastic plasma cells, in our institution, other ancillary studies, including in situ hybridization, flow cytometric analyses of plasma cell surface markers and cytoplasmic immunoglobulins with DNA ploidy, are also utilized routinely.
resultsWe present two cases of plasma cell myeloma in which the neoplastic plasma cells shows production of cytoplasmic kappa and lambda light chain, with secretion of free lambda light chain only. Co-expression of kappa and lambda light chain by the same neoplastic plasma cells is a rare but reported phenomenon.
conclusionsOur study indicates that serum electrophoresis alone could mischaracterize biphenotypic myeloma as monotypic plasma cell myelomas in the absence of additional testing methods.
Indexed as
Identifiers
26339430PMC4555758W2218447560What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.