Evidence map›Paper›PMID 26339424›Full record

ArticleInternational journal of clinical and experimental pathology2015

Clinicopathological classification and traditional prognostic indicators of breast cancer.

Jiehua Li, Zhibai Chen, Ka Su, Jian Zeng

Abstract readEvaluation Study
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Efficacy of Saffron (Integrative cancer therapies
    Pooled it
  5. Number of positive lymph nodes combined with the logarithmic ratio of positive lymph nodes predicts long-term survival for patients with node-positive parotid gland carcinoma after surgery: a SEER population-based study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
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  16. Epidemiological and clinical factors of breast cancer in a population of mostly Afro-descendant women.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiehua LiDepartment of Gastrointestinal and Gland Surgery, The First Affiliated Hospital of Guangxi Medical University Nanning 530021, Guangxi Province, China.
Zhibai ChenDepartment of Gastrointestinal and Gland Surgery, The First Affiliated Hospital of Guangxi Medical University Nanning 530021, Guangxi Province, China.
Ka SuDepartment of Gastrointestinal and Gland Surgery, The First Affiliated Hospital of Guangxi Medical University Nanning 530021, Guangxi Province, China.
Jian ZengDepartment of Gastrointestinal and Gland Surgery, The First Affiliated Hospital of Guangxi Medical University Nanning 530021, Guangxi Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is a heterogeneous disease with molecular subtypes that have biological distinctness and different behavior. The objective of this study is to evaluate the value of molecular subtypes in breast cancer management according to a retrospective analysis of breast carcinoma molecular subtypes, histopathological grade, and TNM stage. A retrospective study of 475 paraffin-embedded tissues of breast cancer samples from the First Affiliated Hospital of Guangxi Medical University was performed. Expression of ER, PR, Her-2 and Ki-67 was analyzed to classify molecular subtypes of breast cancer by immunohistochemistry. The differences of molecular subtypes of breast cancers in regard to TNM staging and pathological grade were analyzed using χ(2) tests. Values of P<0.05 were considered statistically significant. The frequency of luminal A, luminal B, HER2-positive luminal B, triple negative and non-luminal HER2-positive subtypes were: 35.5%, 22.5%, 13.1%, 15.2% and 13.7%, respectively. Among the five subtypes of breast cancer, the distribution of pathological grades showed a significant difference (P<0.001). There were significant differences in the distribution of TNM staging among the five subtypes of breast cancer (P<0.001). In addition to traditional prognostic indicators such as TNM staging and pathological grade, molecular subtype may aid clinical practice and research into breast cancer. Different molecular subtypes will lead to different prognosis and therapeutic option. Molecular subtyping is essential for breast cancer management.

Indexed as

Biomarkers, TumorBreast NeoplasmsChinaChi-Square DistributionFemaleHumansImmunohistochemistryNeoplasm GradingNeoplasm StagingPredictive Value of TestsRetrospective StudiesRisk FactorsBiomarkers, Tumorbreast cancerClinicopathological classificationhistopathological gradetumor-nodal-metastatic staging

Identifiers

PMID26339424
PMCPMC4555752

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.